Natasha Ramakrishnan
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Explore the profile of Natasha Ramakrishnan including associated specialties, affiliations and a list of published articles.
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5
Citations
12
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Recent Articles
1.
Ramakrishnan N, Weaver T, Aubuchon L, Woldegerima A, Just T, Song K, et al.
Nat Commun
. 2024 Jul;
15(1):6343.
PMID: 39068174
Clinical success with poly (ADP-ribose) polymerase inhibitors (PARPi) is impeded by inevitable resistance and associated cytotoxicity. Depletion of Amplified in Liver Cancer 1 (ALC1), a chromatin-remodeling enzyme, can overcome these...
2.
Ramakrishnan N, Malachowski T, Verma P
Methods Cell Biol
. 2024 Feb;
182:299-312.
PMID: 38359984
Probing epistasis between two genes can be a critical first step in identifying the molecular players in a cellular pathway. The advent of CRISPR-Cas mediated genetic screen has enabled studying...
3.
Ramakrishnan N, Haseljic E, Verma P
J Vis Exp
. 2023 Feb;
(192).
PMID: 36847367
Replication stress is a hallmark of several ovarian cancers. Replication stress can emerge from multiple sources, including double-strand breaks, transcription-replication conflicts, or amplified oncogenes, inevitably resulting in the generation of...
4.
Meroni A, Grosser J, Agashe S, Ramakrishnan N, Jackson J, Verma P, et al.
Sci Adv
. 2022 Dec;
8(49):eabq0648.
PMID: 36490343
DNA topoisomerase 1 (TOP11) inhibitors are mainstays of anticancer therapy. These drugs trap TOP1 on DNA, stabilizing the TOP1-cleavage complex (TOP1-cc). The accumulation of TOP1-ccs perturbs DNA replication fork progression,...
5.
Mathyer M, Brettmann E, Schmidt A, Goodwin Z, Oh I, Quiggle A, et al.
Nat Commun
. 2021 May;
12(1):2557.
PMID: 33963188
The genetic modules that contribute to human evolution are poorly understood. Here we investigate positive selection in the Epidermal Differentiation Complex locus for skin barrier adaptation in diverse HapMap human...