Natalie Hawryluk
Overview
Explore the profile of Natalie Hawryluk including associated specialties, affiliations and a list of published articles.
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10
Citations
54
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Recent Articles
1.
Adam A, Besson D, Bryant R, Rees S, Willis P, Burrows J, et al.
ACS Infect Dis
. 2024 Nov;
10(12):4030-4039.
PMID: 39488746
The coronavirus pandemic outbreak of 2019 highlighted the critical importance of preparedness for current and future public health threats (https://www.mmv.org/mmv-open/global-health-priority-box/about-global-health-priority-box). While the main attention for the past few years has...
2.
Hawryluk N, Robinson D, Shen Y, Kyne G, Bedore M, Menon S, et al.
J Med Chem
. 2022 Aug;
65(16):11388-11403.
PMID: 35972896
Filarial diseases, including lymphatic filariasis and onchocerciasis, are considered among the most devastating of all tropical diseases, affecting about 145 million people worldwide. Efforts to control and eliminate onchocerciasis are...
3.
Hawryluk N, Zhiru L, Carlow C, Gokool S, Townson S, Kreiss T, et al.
Int J Parasitol Drugs Drug Resist
. 2022 Jul;
19:89-97.
PMID: 35834918
Filarial diseases, including lymphatic filariasis and onchocerciasis, are considered among the most devastating of all tropical diseases, affecting over 86 million people worldwide. To control and more rapidly eliminate onchocerciasis...
4.
Tasneen R, Mortensen D, Converse P, Urbanowski M, Upton A, Fotouhi N, et al.
Antimicrob Agents Chemother
. 2021 Apr;
65(7):e0025321.
PMID: 33903099
Efforts to develop more effective and shorter-course therapies for tuberculosis have included a focus on host-directed therapy (HDT). The goal of HDT is to modulate the host response to infection,...
5.
Bryk R, Mundhra S, Jiang X, Wood M, Pfau D, Weber E, et al.
PLoS Pathog
. 2020 Jun;
16(6):e1008567.
PMID: 32574211
Efforts at host-directed therapy of tuberculosis have produced little control of the disease in experimental animals to date. This is not surprising, given that few specific host targets have been...
6.
Tummalapalli S, Bhat R, Chojnowski A, Prorok M, Kreiss T, Goldberg R, et al.
ACS Med Chem Lett
. 2018 Mar;
9(3):210-214.
PMID: 29541362
Lymphatic filariasis infects over 120 million people worldwide and can lead to significant disfigurement and disease. Resistance is emerging with current treatments, and these therapies have dose limiting adverse events;...
7.
Mundhra S, Bryk R, Hawryluk N, Zhang T, Jiang X, Nathan C
Eur J Immunol
. 2018 Feb;
48(4):612-620.
PMID: 29436711
Genetic deficiency of protein kinase R (PKR) in mice was reported to enhance macrophage activation in vitro in response to interferon-γ (IFNγ) and to reduce the burden of Mycobacterium tuberculosis...
8.
Keith J, Hawryluk N, Apodaca R, Chambers A, Pierce J, Seierstad M, et al.
Bioorg Med Chem Lett
. 2014 Feb;
24(5):1280-4.
PMID: 24513048
A series of 1-aryl-2-(((6-aryl)pyrimidin-4-yl)amino)ethanols have been found to be competitive inhibitors of fatty acid amide hydrolase (FAAH). One member of this class, JNJ-40413269, was found to have excellent pharmacokinetic properties,...
9.
Tichenor M, Keith J, Jones W, Pierce J, Merit J, Hawryluk N, et al.
Bioorg Med Chem Lett
. 2012 Nov;
22(24):7357-62.
PMID: 23141911
The structure-activity relationships for a series of heteroaryl urea inhibitors of fatty acid amide hydrolase (FAAH) are described. Members of this class of inhibitors have been shown to inactivate FAAH...
10.
McClure K, Maher M, Wu N, Chaplan S, Eckert 3rd W, Lee D, et al.
Bioorg Med Chem Lett
. 2011 Aug;
21(18):5197-201.
PMID: 21824780
The discovery of a series of novel, potent, and selective blockers of the cyclic nucleotide-modulated channel HCN1 is disclosed. Here we report an SAR study around a series of selective...