Naseem Akhtar Gaur
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Explore the profile of Naseem Akhtar Gaur including associated specialties, affiliations and a list of published articles.
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8
Citations
141
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Recent Articles
1.
Arya K, Usmani S, Chandra S, Chaturvedi S, Ali B, Kumar M, et al.
Microb Pathog
. 2025 Feb;
200:107362.
PMID: 39922471
Despite the prevalence of dermatophytosis which affects a quarter of the world's population, there is a pressing need for innovative and effective treatment strategies. Targeting lipid structures and their biosynthetic...
2.
Usmani S, Kumar M, Arya K, Ali B, Bhardwaj N, Gaur N, et al.
Res Microbiol
. 2023 Jun;
174(7):104087.
PMID: 37328042
Sphingolipids (SLs) are essential to fungal survival and represent a major class of structural and signaling lipids. Unique SL structures and their biosynthetic enzymes in filamentous fungi make them an...
3.
Manoharlal R, Gaur N, Panwar S, Morschhauser J, Prasad R
Antimicrob Agents Chemother
. 2008 Feb;
52(4):1481-92.
PMID: 18268086
Many azole-resistant (AR) clinical isolates of Candida albicans display increased expression of the drug transporters CDR1 and CDR2. In this study, we evaluate the molecular mechanisms that contribute to the...
4.
Saini P, Gaur N, Prasad R
Microbiology (Reading)
. 2006 Apr;
152(Pt 5):1559-1573.
PMID: 16622073
The molecular basis of the broad substrate recognition and the transport of substrates by Cdr1p, a major drug efflux protein of Candida albicans, is not well understood. To investigate the...
5.
Prasad T, Saini P, Gaur N, Vishwakarma R, Khan L, Haq Q, et al.
Antimicrob Agents Chemother
. 2005 Jul;
49(8):3442-52.
PMID: 16048959
In the present study we describe the isolation and functional analysis of a sphingolipid biosynthetic gene, IPT1, of Candida albicans. The functional consequence of the disruption of both alleles of...
6.
Saini P, Prasad T, Gaur N, Shukla S, Jha S, Komath S, et al.
J Antimicrob Chemother
. 2005 Jun;
56(1):77-86.
PMID: 15937063
Objectives: To investigate the role of transmembrane segment 11 (TMS11) of Candida albicans drug resistance protein (Cdr1p) in drug extrusion. Methods: We replaced each of the 21 putative residues of...
7.
Gaur N, Manoharlal R, Saini P, Prasad T, Mukhopadhyay G, Hoefer M, et al.
Biochem Biophys Res Commun
. 2005 May;
332(1):206-14.
PMID: 15896319
Resistance to azole antifungal drugs in clinical isolates of the human fungal pathogen Candida albicans is often caused by constitutive overexpression of the CDR1 gene, which encodes a multidrug efflux...
8.
Karnani N, Gaur N, Jha S, Puri N, Krishnamurthy S, Goswami S, et al.
Yeast
. 2004 Feb;
21(3):219-39.
PMID: 14968428
CDR1 gene encoding an ATP-driven drug extrusion pump has been implicated in the development of azole-resistance in Candida albicans. Although the upregulation of CDR1 expression by various environmental factors has...
9.
Gaur N, Puri N, Karnani N, Mukhopadhyay G, Goswami S, Prasad R
FEMS Yeast Res
. 2004 Jan;
4(4-5):389-99.
PMID: 14734019
We have earlier shown that transcriptional activation of the Candida drug resistance gene, CDR1, is linked to various stresses wherein a proximal promoter (-345 bp from the transcription start point...