Naoki Osato
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Explore the profile of Naoki Osato including associated specialties, affiliations and a list of published articles.
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24
Citations
1703
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Recent Articles
1.
Zeng C, Takeda A, Sekine K, Osato N, Fukunaga T, Hamada M
Methods Mol Biol
. 2022 Jul;
2509:315-340.
PMID: 35796972
With a large number of annotated non-coding RNAs (ncRNAs), repetitive sequences are found to constitute functional components (termed as repetitive elements) in ncRNAs that perform specific biological functions. Bioinformatics analysis...
2.
Iwase M, Tokiwa S, Seno S, Mukai T, Yeh Y, Takahashi H, et al.
J Biol Chem
. 2020 Apr;
295(20):7033-7045.
PMID: 32273338
Browning of adipose tissue is induced by specific stimuli such as cold exposure and consists of up-regulation of thermogenesis in white adipose tissue. Recently, it has emerged as an attractive...
3.
Nakato R, Wada Y, Nakaki R, Nagae G, Katou Y, Tsutsumi S, et al.
Epigenetics Chromatin
. 2019 Dec;
12(1):77.
PMID: 31856914
Background: Endothelial cells (ECs) make up the innermost layer throughout the entire vasculature. Their phenotypes and physiological functions are initially regulated by developmental signals and extracellular stimuli. The underlying molecular...
4.
Sharma A, Osato N, Liu H, Asthana S, Dakal T, Ambrosini G, et al.
Sci Rep
. 2019 Dec;
9(1):18464.
PMID: 31804560
Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of α-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost...
5.
Iwase M, Sakai S, Seno S, Yeh Y, Kuo T, Takahashi H, et al.
Biosci Biotechnol Biochem
. 2019 Oct;
84(2):305-313.
PMID: 31601163
Specific conditions, such as exposure to cold, can induce the production of brown-like adipocytes in white adipose tissue. These adipocytes express high levels of uncoupling protein 1 (UCP1) and energy...
6.
Sota Y, Seno S, Shigeta H, Osato N, Shimoda M, Noguchi S, et al.
J Bioinform Comput Biol
. 2019 Jul;
17(3):1940008.
PMID: 31288642
Fusion genes are involved in cancer, and their detection using RNA-Seq is insufficient given the relatively short reading length. Therefore, we proposed a shifted short-read clustering (SSC) method, which focuses...
7.
Takeda K, Sawazaki H, Takahashi H, Yeh Y, Jheng H, Nomura W, et al.
FEBS Open Bio
. 2018 Nov;
8(11):1782-1793.
PMID: 30410858
To clarify the effects of a dipeptidyl peptidase-4 (DPP-4) inhibitor on whole-body energy metabolism, we treated mice fed a high-fat diet (HFD) with teneligliptin, a clinically available DPP-4 inhibitor. Teneligliptin...
8.
Osato N
BMC Genomics
. 2018 Jan;
19(Suppl 1):957.
PMID: 29363429
Background: Transcriptional target genes show functional enrichment of genes. However, how many and how significantly transcriptional target genes include functional enrichments are still unclear. To address these issues, I predicted...
9.
Sasaki H, Kurotaki D, Osato N, Sato H, Sasaki I, Koizumi S, et al.
Blood
. 2014 Nov;
125(2):358-69.
PMID: 25398936
Basophils and mast cells play critical roles in host defense against pathogens and allergic disorders. However, the molecular mechanism by which these cells are generated is not completely understood. Here...
10.
Kurotaki D, Osato N, Nishiyama A, Yamamoto M, Ban T, Sato H, et al.
Blood
. 2013 Jan;
121(10):1839-49.
PMID: 23319570
Monocytes regulate host defenses, inflammation, and tissue homeostasis. The transcription factor interferon regulatory factor-8 (IRF8) stimulates monocyte/macrophage differentiation, yet genome-wide understanding of the differentiation program initiated by IRF8 is lacking....