Naoki Kanoh
Overview
Explore the profile of Naoki Kanoh including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
66
Citations
391
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Watanabe Y, Haneda T, Kimishima A, Kuwae A, Suga T, Suzuki T, et al.
Proc Natl Acad Sci U S A
. 2024 Apr;
121(17):e2322363121.
PMID: 38640341
Anti-microbial resistance (AMR) is one of the greatest threats to global health. The continual battle between the emergence of AMR and the development of drugs will be extremely difficult to...
2.
Huang Y, Yokoe H, Kaiho-Soma A, Takahashi K, Hirasawa Y, Morita H, et al.
Bioconjug Chem
. 2023 Aug;
34(9):1716-1717.
PMID: 37642326
No abstract available.
3.
Tateishi Y, Sato R, Komatsu S, Noguchi M, Nagasawa S, Sasano Y, et al.
Angew Chem Int Ed Engl
. 2023 May;
62(29):e202303140.
PMID: 37212460
Cytotrienin A, an ansamycin-class antibiotic, exhibits potent apoptosis-inducing activity and has attracted much attention as a lead compound for anticancer drugs. Herein, we report a new asymmetric synthetic route to...
4.
-Selective Double Spirocyclization via Dearomatization and Isomerization under Thermodynamic Control
Yokoe H, Kiriyama A, Shimoda M, Nakajima S, Hashizume Y, Endo Y, et al.
J Org Chem
. 2023 Jan;
88(3):1803-1814.
PMID: 36632764
Spiro compounds have been considered key scaffolds for pharmaceutical applications. Although many synthetic methods exist for monospirocycles, fewer approaches are known for dispirocycles. Here, we report a highly -selective method...
5.
Huang Y, Yokoe H, Kaiho-Soma A, Takahashi K, Hirasawa Y, Morita H, et al.
Bioconjug Chem
. 2021 Dec;
33(1):142-151.
PMID: 34878263
Trivalent PROTACs having a functionalization site with controlled orientation were designed, synthesized, and evaluated. Based on the X-ray structure of BRD protein degrader MZ1 () in complex with human VHL...
6.
Kanoh N, Terajima Y, Tanaka S, Terashima R, Nishiyama H, Nagasawa S, et al.
J Org Chem
. 2021 Nov;
86(23):16231-16248.
PMID: 34797655
A highly modular synthetic strategy for the heronamide C-type polyene macrolactams was established by synthesizing 8-deoxyheronamide C (). The developed strategy enabled not only the total synthesis of 8-deoxyheronamide C...
7.
Kanoh N, Terashima R, Nishiyama H, Terajima Y, Nagasawa S, Sasano Y, et al.
J Org Chem
. 2021 Nov;
86(23):16249-16258.
PMID: 34784214
16,17-Dihydroheronamide C () and -heronamide C (-) were designed as probes for the mode-of-action analysis of heronamide C (). These molecules were synthesized by utilizing a highly modular strategy developed...
8.
Segawa R, Takeda H, Yokoyama T, Ishida M, Miyata C, Saito T, et al.
Biochem Pharmacol
. 2021 Nov;
194:114819.
PMID: 34757034
Although treatments for allergic diseases have improved, side effects and treatment resistance remain as challenges. New therapeutic drugs for allergic diseases are urgently required. Thymic stromal lymphopoietin (TSLP) is a...
9.
Okamura T, Koyamada K, Kanazawa J, Miyamoto K, Iwabuchi Y, Uchiyama M, et al.
J Org Chem
. 2020 Dec;
86(2):1911-1924.
PMID: 33284629
With the increasing importance of fluorine to medicinal chemistry and other areas, methods to access various fluorinated compounds are needed. Herein, we report the synthesis of difluoropropargyl vinyl ethers from...
10.
Yokoe H, Mizumura Y, Sugiyama K, Yan K, Hashizume Y, Endo Y, et al.
Chem Asian J
. 2020 Oct;
15(24):4271-4274.
PMID: 33029940
Here we describe the diastereoselective synthesis of (5r,8r)-1,9-diazadispiro[4.2.4 .2 ]tetradecatrienes via domino double spirocyclization of N-arylamide derivatives. This reaction can serve as a fast way to synthesize diazadispirocycles, which are...