Rapid Access to Dispirocyclic Scaffolds Enabled by Diastereoselective Intramolecular Double Functionalization of Benzene Rings

Overview

Journal Chem Asian J

Specialty Chemistry

Date 2020 Oct 8

PMID 33029940

Citations 1

Authors

Hiromasa Yokoe

Yuka Mizumura

Kana Sugiyama

Kejia Yan

Yuna Hashizume

Yuto Endo

Sae Yoshida

Akiko Kiriyama

Masayoshi Tsubuki

Naoki Kanoh

Affiliations

Soon will be listed here.

Abstract

Here we describe the diastereoselective synthesis of (5r,8r)-1,9-diazadispiro[4.2.4 .2 ]tetradecatrienes via domino double spirocyclization of N-arylamide derivatives. This reaction can serve as a fast way to synthesize diazadispirocycles, which are found in the core structures of bioactive natural products. Product diversification via Suzuki-Miyaura cross coupling and application to the synthesis of 1-oxa-9-azadispiro[4.2.4 .2 ]tetradecatrienes were also conducted.

Citing Articles

Rapid Access to Dispirocyclic Scaffolds Enabled by Diastereoselective Intramolecular Double Functionalization of Benzene Rings.

Yokoe H, Mizumura Y, Sugiyama K, Yan K, Hashizume Y, Endo Y Chem Asian J. 2020; 15(24):4271-4274.

PMID: 33029940 PMC: 7756633. DOI: 10.1002/asia.202001179.

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