Nancy E Hasselt
Overview
Explore the profile of Nancy E Hasselt including associated specialties, affiliations and a list of published articles.
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9
Citations
1037
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0
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Recent Articles
1.
Westerhout E, Hamdi M, Stroeken P, Nowakowska N, Lakeman A, van Arkel J, et al.
Cancer Res
. 2022 Jul;
82(14):2657.
PMID: 35844173
No abstract available.
2.
Westerhout E, Hamdi M, Stroeken P, Nowakowska N, Lakeman A, van Arkel J, et al.
Cancer Res
. 2021 Dec;
82(3):484-496.
PMID: 34853072
Cancer therapy frequently fails due to the emergence of resistance. Many tumors include phenotypically immature tumor cells, which have been implicated in therapy resistance. Neuroblastoma cells can adopt a lineage-committed...
3.
A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
van Groningen T, Akogul N, Westerhout E, Chan A, Hasselt N, Zwijnenburg D, et al.
Nat Commun
. 2019 Apr;
10(1):1530.
PMID: 30948783
Transition between differentiation states in development occurs swift but the mechanisms leading to epigenetic and transcriptional reprogramming are poorly understood. The pediatric cancer neuroblastoma includes adrenergic (ADRN) and mesenchymal (MES)...
4.
van Groningen T, Koster J, Valentijn L, Zwijnenburg D, Akogul N, Hasselt N, et al.
Nat Genet
. 2017 Jun;
49(8):1261-1266.
PMID: 28650485
Neuroblastoma and other pediatric tumors show a paucity of gene mutations, which has sparked an interest in their epigenetic regulation. Several tumor types include phenotypically divergent cells, resembling cells from...
5.
Valentijn L, Koster J, Zwijnenburg D, Hasselt N, van Sluis P, Volckmann R, et al.
Nat Genet
. 2015 Nov;
47(12):1411-4.
PMID: 26523776
Whole-genome sequencing detected structural rearrangements of TERT in 17 of 75 high-stage neuroblastomas, with five cases resulting from chromothripsis. Rearrangements were associated with increased TERT expression and targeted regions immediately...
6.
Bunt J, Hasselt N, Zwijnenburg D, Koster J, Versteeg R, Kool M
PLoS One
. 2011 Oct;
6(10):e26058.
PMID: 22016811
Both OTX2 and MYC are important oncogenes in medulloblastoma, the most common malignant brain tumor in childhood. Much is known about MYC binding to promoter regions, but OTX2 binding is...
7.
Bunt J, Hasselt N, Zwijnenburg D, Hamdi M, Koster J, Versteeg R, et al.
Int J Cancer
. 2011 Oct;
131(2):E21-32.
PMID: 21964830
The transcription factor OTX2 has been implicated as an oncogene in medulloblastoma, which is the most common malignant brain tumor in children. It is highly expressed in most medulloblastomas and...
8.
Bunt J, de Haas T, Hasselt N, Zwijnenburg D, Koster J, Versteeg R, et al.
Mol Cancer Res
. 2010 Nov;
8(10):1344-57.
PMID: 21047732
The transcription factor orthodenticle homeobox 2 (OTX2) has been implicated in the pathogenesis of medulloblastoma, as it is often highly expressed and sometimes amplified in these tumors. Little is known...
9.
Kool M, Koster J, Bunt J, Hasselt N, Lakeman A, van Sluis P, et al.
PLoS One
. 2008 Sep;
3(8):e3088.
PMID: 18769486
Background: Medulloblastoma is the most common malignant brain tumor in children. Despite recent improvements in cure rates, prediction of disease outcome remains a major challenge and survivors suffer from serious...