Linda J Valentijn
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Explore the profile of Linda J Valentijn including associated specialties, affiliations and a list of published articles.
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19
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1737
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Recent Articles
1.
Westerhout E, Hamdi M, Stroeken P, Nowakowska N, Lakeman A, van Arkel J, et al.
Cancer Res
. 2022 Jul;
82(14):2657.
PMID: 35844173
No abstract available.
2.
Verly I, Matser Y, Leen R, Meinsma R, Fiocco M, Koster J, et al.
JCO Precis Oncol
. 2022 Jan;
6:e2000447.
PMID: 35085004
Purpose: Elevated urinary 3-methoxytyramine (3MT) level at diagnosis was recently put forward as independent risk factor for poor prognosis in neuroblastoma. Here, we investigated the biologic basis underlying the putative...
3.
Westerhout E, Hamdi M, Stroeken P, Nowakowska N, Lakeman A, van Arkel J, et al.
Cancer Res
. 2021 Dec;
82(3):484-496.
PMID: 34853072
Cancer therapy frequently fails due to the emergence of resistance. Many tumors include phenotypically immature tumor cells, which have been implicated in therapy resistance. Neuroblastoma cells can adopt a lineage-committed...
4.
A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
van Groningen T, Akogul N, Westerhout E, Chan A, Hasselt N, Zwijnenburg D, et al.
Nat Commun
. 2019 Apr;
10(1):1530.
PMID: 30948783
Transition between differentiation states in development occurs swift but the mechanisms leading to epigenetic and transcriptional reprogramming are poorly understood. The pediatric cancer neuroblastoma includes adrenergic (ADRN) and mesenchymal (MES)...
5.
van Groningen T, Koster J, Valentijn L, Zwijnenburg D, Akogul N, Hasselt N, et al.
Nat Genet
. 2017 Jun;
49(8):1261-1266.
PMID: 28650485
Neuroblastoma and other pediatric tumors show a paucity of gene mutations, which has sparked an interest in their epigenetic regulation. Several tumor types include phenotypically divergent cells, resembling cells from...
6.
Eberhardt A, Hansen J, Koster J, Lotta Jr L, Wang S, Livingstone E, et al.
Oncotarget
. 2016 Aug;
7(39):63629-63639.
PMID: 27571165
Amplification or overexpression of MYCN is associated with poor prognosis of human neuroblastoma. We have recently defined a MYCN-dependent transcriptional signature, including protein arginine methyltransferase 1 (PRMT1), which identifies a...
7.
Valentijn L, Koster J, Zwijnenburg D, Hasselt N, van Sluis P, Volckmann R, et al.
Nat Genet
. 2015 Nov;
47(12):1411-4.
PMID: 26523776
Whole-genome sequencing detected structural rearrangements of TERT in 17 of 75 high-stage neuroblastomas, with five cases resulting from chromothripsis. Rearrangements were associated with increased TERT expression and targeted regions immediately...
8.
Mandriota S, Valentijn L, Lesne L, Betts D, Marino D, Boudal-Khoshbeen M, et al.
Oncotarget
. 2015 Jun;
6(21):18558-76.
PMID: 26053094
Neuroblastoma, a childhood cancer with highly heterogeneous biology and clinical behavior, is characterized by genomic aberrations including amplification of MYCN. Hemizygous deletion of chromosome 11q is a well-established, independent marker...
9.
Valentijn L, Koster J, Haneveld F, Aissa R, van Sluis P, Broekmans M, et al.
Proc Natl Acad Sci U S A
. 2012 Oct;
109(47):19190-5.
PMID: 23091029
Neuroblastoma is a pediatric tumor of the sympathetic nervous system. MYCN (V-myc myelocytomatosis viral-related oncogene, neuroblastoma derived [avian]) is amplified in 20% of neuroblastomas, and these tumors carry a poor...
10.
Molenaar J, Domingo-Fernandez R, Ebus M, Lindner S, Koster J, Drabek K, et al.
Nat Genet
. 2012 Oct;
44(11):1199-206.
PMID: 23042116
LIN28B regulates developmental processes by modulating microRNAs (miRNAs) of the let-7 family. A role for LIN28B in cancer has been proposed but has not been established in vivo. Here, we...