Nahid Dadgar
Overview
Explore the profile of Nahid Dadgar including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
345
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Recent Articles
1.
Elrick M, Pacheco C, Yu T, Dadgar N, Shakkottai V, Ware C, et al.
Hum Mol Genet
. 2009 Dec;
19(5):837-47.
PMID: 20007718
Pathways regulating neuronal vulnerability are poorly understood, yet are central to identifying therapeutic targets for degenerative neurological diseases. Here, we characterize mechanisms underlying neurodegeneration in Niemann-Pick type C (NPC) disease,...
2.
Mukherjee S, Thomas M, Dadgar N, Lieberman A, Iniguez-Lluhi J
J Biol Chem
. 2009 Jun;
284(32):21296-306.
PMID: 19497852
The neurodegenerative disorder spinal and bulbar muscular atrophy or Kennedy disease is caused by a CAG trinucleotide repeat expansion within the androgen receptor (AR) gene. The resulting expanded polyglutamine tract...
3.
Yu Z, Dadgar N, Albertelli M, Gruis K, Jordan C, Robins D, et al.
J Clin Invest
. 2006 Sep;
116(10):2663-72.
PMID: 16981011
Kennedy disease, a degenerative disorder characterized by androgen-dependent neuromuscular weakness, is caused by a CAG/glutamine tract expansion in the androgen receptor (Ar) gene. We developed a mouse model of Kennedy...
4.
Yu Z, Dadgar N, Albertelli M, Scheller A, Albin R, Robins D, et al.
Am J Pathol
. 2006 Jan;
168(1):195-204.
PMID: 16400023
An unresolved question in the study of the polyglutamine neurodegenerative disorders is the extent to which partial loss of normal function of the mutant protein contributes to the disease phenotype....
5.
Thomas M, Yu Z, Dadgar N, Varambally S, Yu J, Chinnaiyan A, et al.
J Biol Chem
. 2005 Apr;
280(22):21264-71.
PMID: 15799970
Kennedy disease, a degenerative disorder caused by an expanded glutamine tract, is mediated by misfolding of the mutant androgen receptor (AR) protein, a process that may disrupt proteasome function. We...
6.
Thomas M, Dadgar N, Aphale A, Harrell J, Kunkel R, Pratt W, et al.
J Biol Chem
. 2003 Dec;
279(9):8389-95.
PMID: 14670946
Kennedy's disease is a degenerative disorder of motor neurons caused by the expansion of a glutamine tract near the amino terminus of the androgen receptor (AR). Ligand binding to the...