Nagendra S Singh
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Explore the profile of Nagendra S Singh including associated specialties, affiliations and a list of published articles.
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14
Citations
888
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Recent Articles
1.
Faccio A, Ruperez F, Singh N, Angulo S, Tavares M, Bernier M, et al.
Biochim Biophys Acta Gen Subj
. 2018 Mar;
1862(6):1505-1515.
PMID: 29526507
Background: Impairment in mitochondrial biogenesis and function plays a key role in depression and anxiety, both of which being associated with changes in fatty acid and phospholipid metabolism. The antidepressant...
2.
Bernier M, Catazaro J, Singh N, Wnorowski A, Boguszewska-Czubara A, Jozwiak K, et al.
Int J Cancer
. 2017 Jul;
141(10):2131-2142.
PMID: 28741686
The Warburg effect is a predominant metabolic pathway in cancer cells characterized by enhanced glucose uptake and its conversion to l-lactate and is associated with upregulated expression of HIF-1α and...
3.
Zanos P, Moaddel R, Morris P, Georgiou P, Fischell J, Elmer G, et al.
Nature
. 2017 Jun;
546(7659):E4-E5.
PMID: 28640272
No abstract available.
4.
Singh N, Bernier M, Wainer I
Pharmacol Res
. 2016 Jul;
111:757-766.
PMID: 27423937
G protein-coupled receptor 55 (GPR55) possesses pro-oncogenic activity and its function can be competitively inhibited with (R,R')-4'-methoxy-1-naphthylfenoterol (MNF) through poorly defined signaling pathways. Here, the anti-tumorigenic effect of MNF was...
5.
Zanos P, Moaddel R, Morris P, Georgiou P, Fischell J, Elmer G, et al.
Nature
. 2016 May;
533(7604):481-6.
PMID: 27144355
Major depressive disorder affects around 16 per cent of the world population at some point in their lives. Despite the availability of numerous monoaminergic-based antidepressants, most patients require several weeks,...
6.
Singh N, Rutkowska E, Plazinska A, Khadeer M, Moaddel R, Jozwiak K, et al.
PLoS One
. 2016 Apr;
11(4):e0149499.
PMID: 27096720
D-Serine is an endogenous NMDA receptor co-agonist that activates synaptic NMDA receptors modulating neuronal networks in the cerebral cortex and plays a key role in long-term potentiation of synaptic transmission....
7.
Singh N, Bernier M, Camandola S, Khadeer M, Moaddel R, Mattson M, et al.
Br J Pharmacol
. 2015 Jul;
172(18):4546-4559.
PMID: 26140427
Background And Purpose: Patients with major depressive disorder receiving racemic ketamine, (R,S)-ketamine, experience transient increases in Clinician-Administered Dissociative States Scale scores and a coincident drop in plasma d-serine levels. The...
8.
Wnorowski A, Sadowska M, Paul R, Singh N, Boguszewska-Czubara A, Jimenez L, et al.
Cell Signal
. 2015 Feb;
27(5):997-1007.
PMID: 25703025
(R,R')-4'-methoxy-1-naphthylfenoterol [(R,R')-MNF] is a highly-selective β2 adrenergic receptor (β2-AR) agonist. Incubation of a panel of human-derived melanoma cell lines with (R,R')-MNF resulted in a dose- and time-dependent inhibition of motility...
9.
Singh N, Zarate Jr C, Moaddel R, Bernier M, Wainer I
Expert Rev Neurother
. 2014 Oct;
14(11):1239-42.
PMID: 25331415
(R,S)-Ketamine was initially developed as an anesthetic agent and its pharmacological properties were determined on the basis of this clinical use. However, pharmacological studies in rat led to the development...
10.
Paul R, Singh N, Khadeer M, Moaddel R, Sanghvi M, Green C, et al.
Anesthesiology
. 2014 Jun;
121(1):149-59.
PMID: 24936922
Background: Subanesthetic doses of (R,S)-ketamine are used in the treatment of neuropathic pain and depression. In the rat, the antidepressant effects of (R,S)-ketamine are associated with increased activity and function...