Nadia J Kershaw
Overview
Explore the profile of Nadia J Kershaw including associated specialties, affiliations and a list of published articles.
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53
Citations
1755
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Recent Articles
1.
Oxley E, Kershaw N, Louis C, Goodall K, Garwood M, Jee Ho S, et al.
Cell Rep
. 2024 Oct;
43(10):114834.
PMID: 39383033
T cell surface CTLA4 sequesters the costimulatory ligands CD80 and CD86 on antigen-presenting cells (APCs) to prevent autoimmunity. Therapeutic immunosuppression by recombinant CTLA4-immunoglobulin (Ig) fusion proteins, including abatacept, is also...
2.
Zhang Y, Morris R, Brown G, Lorenzo A, Meng X, Kershaw N, et al.
J Exp Med
. 2024 Feb;
221(4).
PMID: 38417019
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with a clear genetic component. While most SLE patients carry rare gene variants in lupus risk genes, little is known about...
3.
Sarson-Lawrence K, Hardy J, Iaria J, Stockwell D, Behrens K, Saiyed T, et al.
Nat Commun
. 2024 Feb;
15(1):1135.
PMID: 38326297
Thrombopoietin (Tpo) is the primary regulator of megakaryocyte and platelet numbers and is required for haematopoetic stem cell maintenance. Tpo functions by binding its receptor (TpoR, a homodimeric Class I...
4.
Linossi E, Li K, Veggiani G, Tan C, Dehkhoda F, Hockings C, et al.
Nat Commun
. 2023 Dec;
14(1):7951.
PMID: 38040684
No abstract available.
5.
Liang S, Tran E, Du X, Dong J, Sudholz H, Chen H, et al.
Nat Commun
. 2023 Jul;
14(1):4524.
PMID: 37500611
The inhibition of protein tyrosine phosphatases 1B (PTP1B) and N2 (PTPN2) has emerged as an exciting approach for bolstering T cell anti-tumor immunity. ABBV-CLS-484 is a PTP1B/PTPN2 inhibitor in clinical...
6.
Morris R, Keating N, Tan C, Chen H, Laktyushin A, Saiyed T, et al.
Commun Biol
. 2023 Jun;
6(1):641.
PMID: 37316570
Protein Tyrosine Phosphatase 1B (PTP1B) is the prototypical protein tyrosine phosphatase and plays an essential role in the regulation of several kinase-driven signalling pathways. PTP1B displays a preference for bisphosphorylated...
7.
Low R, Fung K, Gao H, Preaudet A, Dagley L, Yousef J, et al.
Cell Death Differ
. 2023 Mar;
30(5):1400.
PMID: 36949280
No abstract available.
8.
Doggett K, Keating N, Dehkhoda F, Bidgood G, Meza Guzman L, Leong E, et al.
Cytokine
. 2023 Mar;
165:156167.
PMID: 36934508
Suppressor Of Cytokine Signaling (SOCS) 1 is a critical negative regulator of cytokine signaling and required to protect against an excessive inflammatory response. Genetic deletion of Socs1 results in unrestrained...
9.
Low R, Fung K, Gao H, Preaudet A, Dagley L, Yousef J, et al.
Cell Death Differ
. 2023 Feb;
30(5):1155-1165.
PMID: 36828915
Epithelial-mesenchymal transition (EMT) is a continuum that includes epithelial, partial EMT, and mesenchymal states, each of which is associated with cancer progression, invasive capabilities, and ultimately, metastasis. We used a...
10.
Li K, Meza Guzman L, Whitehead L, Leong E, Kueh A, Alexander W, et al.
Biosci Rep
. 2022 Nov;
42(12).
PMID: 36398696
Suppressor of cytokine signaling (SOCS) 2 is the critical negative regulator of growth hormone (GH) and prolactin signaling. Mice lacking SOCS2 display gigantism with increased body weight and length, and...