Nader Al Nakouzi
Overview
Explore the profile of Nader Al Nakouzi including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
606
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0
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Recent Articles
1.
Fyke Z, Johansson R, Scott A, Wiley D, Chelsky D, Zak J, et al.
Mol Genet Metab
. 2024 Jul;
143(1-2):108537.
PMID: 39033629
Infantile neuronal ceroid lipofuscinosis (CLN1 Batten Disease) is a devastating pediatric lysosomal storage disease caused by pathogenic variants in the CLN1 gene, which encodes the depalmitoylation enzyme, palmitoyl-protein thioesterase 1...
2.
Farivar N, Khazamipour N, Roberts M, Nelepcu I, Marzban M, Moeen A, et al.
Small
. 2024 Mar;
20(32):e2309495.
PMID: 38511548
Photothermal therapy (PTT) refers to the use of plasmonic nanoparticles to convert electromagnetic radiation in the near infrared region to heat and kill tumor cells. Continuous wave lasers have been...
3.
Wang C, Nelepcu I, Hui D, Oo H, Truong S, Zhao S, et al.
Sci Rep
. 2022 Feb;
12(1):3075.
PMID: 35197518
Proteoglycans are proteins that are modified with glycosaminoglycan chains. Chondroitin sulfate proteoglycans (CSPGs) are currently being exploited as targets for drug-delivery in various cancer indications, however basic knowledge on how...
4.
Muller I, Strozyk E, Schindler S, Beissert S, Oo H, Sauter T, et al.
Mol Cell
. 2020 Jan;
77(5):970-984.e7.
PMID: 31982308
Cytosolic caspase-8 is a mediator of death receptor signaling. While caspase-8 expression is lost in some tumors, it is increased in others, indicating a conditional pro-survival function of caspase-8 in...
5.
Nappi L, Aguda A, Al Nakouzi N, Lelj-Garolla B, Beraldi E, Lallous N, et al.
J Clin Invest
. 2019 Dec;
130(2):699-714.
PMID: 31845908
HSP27 is highly expressed in, and supports oncogene addiction of, many cancers. HSP27 phosphorylation is a limiting step for activation of this protein and a target for inhibition, but its...
6.
Garrido M, Martin N, Bertrand M, Gaudin C, Commo F, El Kalaany N, et al.
Clin Cancer Res
. 2018 Oct;
25(2):710-723.
PMID: 30322877
Purpose: Targeted therapies that use the signaling pathways involved in prostate cancer are required to overcome chemoresistance and improve treatment outcomes for men. Molecular chaperones play a key role in...
7.
Todenhofer T, Seiler R, Stewart C, Moskalev I, Gao J, Ladhar S, et al.
Mol Cancer Ther
. 2018 Sep;
17(12):2746-2755.
PMID: 30262589
The significance of lactate transporters has been recognized in various cancer types, but their role in urothelial carcinoma remains mostly unknown. The aim of this study was to investigate the...
8.
Li N, Truong S, Nouri M, Moore J, Al Nakouzi N, Lubik A, et al.
Oncogene
. 2018 Feb;
37(17):2313-2325.
PMID: 29429990
Hedgehog (Hh) is an oncogenic signaling pathway that regulates the activity of Gli transcription factors. Canonical Hh is a Smoothened- (Smo-) driven process that alters the post-translational processing of Gli2/Gli3...
9.
Peacock J, Takeuchi A, Hayashi N, Liu L, Tam K, Al Nakouzi N, et al.
EMBO Mol Med
. 2018 Jan;
10(2):219-238.
PMID: 29348142
Growth factor receptor tyrosine kinase (RTK) pathway activation is a key mechanism for mediating cancer growth, survival, and treatment resistance. Cognate ligands play crucial roles in autocrine or paracrine stimulation...
10.
Lallous N, Leblanc E, Munuganti R, Hassona M, Al Nakouzi N, Awrey S, et al.
Mol Cancer Ther
. 2016 Oct;
15(12):2936-2945.
PMID: 27765852
The development of new antiandrogens, such as enzalutamide, or androgen synthesis inhibitors like abiraterone has improved patient outcomes in the treatment of advanced prostate cancer. However, due to the development...