N L Simmons
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Explore the profile of N L Simmons including associated specialties, affiliations and a list of published articles.
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148
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2108
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Recent Articles
1.
Haslam I, Simmons N
J Comp Physiol B
. 2014 Apr;
184(5):673-81.
PMID: 24747985
Rumen fermentation of plant-based forage in bovines is the major site for generation and absorption of short-chain fatty acids. Consequentially, the rumen is also the site for initial exposure to...
2.
Haslam I, Wright J, OReilly D, Sherlock D, Coleman T, Simmons N
Drug Metab Dispos
. 2011 Sep;
39(12):2321-8.
PMID: 21930826
Intestinal secretory movement of the fluoroquinolone antibiotic, ciprofloxacin, may limit its oral bioavailability. Active ATP-binding cassette (ABC) transporters such as breast cancer resistance protein (BCRP) have been implicated in ciprofloxacin...
3.
Charlton J, Simmons N
Toxicol In Vitro
. 2010 Aug;
7(2):129-36.
PMID: 20732180
The phenotypes of the human renal epithelial cell lines, SK-NEP-1 and G401 (Wilm's tumour lines) and ACHN, A498, A704, Caki-1 and Caki-2 (renal adenocarcinomas), were investigated in order to develop...
4.
Broadhead C, Walker D, Skinner R, Simmons N
Toxicol In Vitro
. 2010 Jul;
12(3):209-17.
PMID: 20654403
Ifosfamide (IF) chemotherapy is dependent on bioactivation by cytochrome P-450 and may be limited by concurrent nephrotoxicity. An in vitro approach utilizing the renal cell lines G401, MDCK Strains I...
5.
Simmons N, Chaudhry A, Graham C, Scriven E, Thistlethwaite A, Smith C, et al.
J Anim Sci
. 2009 Jul;
87(10):3288-99.
PMID: 19574570
Facilitative UT-B urea transporters have been located in the gastrointestinal tract of numerous mammalian species. We have previously identified UT-B urea transporters within the epithelial layers of the bovine (b)...
6.
Haslam I, Jones K, Coleman T, Simmons N
Biochem Pharmacol
. 2008 Aug;
76(7):850-61.
PMID: 18703021
Intestinal induction of Pgp is known to limit the oral availability of certain drug compounds and give rise to detrimental drug-drug interactions. We have investigated the induction of P-glycoprotein (Pgp;...
7.
Haslam I, Jones K, Coleman T, Simmons N
Br J Pharmacol
. 2008 Mar;
154(1):246-55.
PMID: 18332862
Background And Purpose: Oral drug bioavailability is limited by intestinal expression of P-glycoprotein (MDR1, Pgp, ABCB1) whose capacity is regulated via nuclear receptors e.g. the pregnane X receptor (PXR, SXR,...
8.
Moochhala S, Sayer J, Carr G, Simmons N
Exp Physiol
. 2007 Oct;
93(1):43-9.
PMID: 17911353
Extracellular pyrophosphate (PPi) plays a central role in the control of normal bone mineralization since it antagonizes inorganic phosphate in the promotion of hydroxyapatite deposition. Studies using knock-out mice have...
9.
Linley J, Simmons N, Gray M
Pflugers Arch
. 2006 Oct;
453(4):487-95.
PMID: 17021797
We have used the perforated patch clamp and fura-2 fluorescence techniques to study the effect of extracellular Zn(2+) on whole-cell Ca(2+)-activated Cl(-) currents (I (CLCA)) in mouse inner medullary collecting...
10.
Graham C, Gatherar I, Haslam I, Glanville M, Simmons N
Am J Physiol Regul Integr Comp Physiol
. 2006 Sep;
292(2):R997-1007.
PMID: 17008462
Monocarboxylate-H+ cotransporters, such as monocarboxylate transporter (MCT) SLC16A, have been suggested to mediate transruminal fluxes of short-chain fatty acids, ketone bodies, and lactate. Using an RT-PCR approach, we demonstrate expression...