N I Hutchinson
Overview
Explore the profile of N I Hutchinson including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
24
Citations
670
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Hutchinson N, Ryder S
Clin Pharmacol Ther
. 2007 Mar;
81(5):756-60.
PMID: 17392723
Obesity is an epidemic with tremendous impact on both patients and health-care systems globally. This paper explores some of the questions related to the clinical development of new pharmacotherapies in...
2.
Mudgett J, Hutchinson N, Chartrain N, Forsyth A, McDonnell J, Singer I, et al.
Arthritis Rheum
. 1998 Jan;
41(1):110-21.
PMID: 9433876
Objective: It has long been proposed that stromelysin is one of the major degradative matrix metalloproteinases responsible for the loss of cartilage in rheumatoid arthritis (RA) and osteoarthritis (OA). This...
3.
Lark M, Bayne E, Flanagan J, Harper C, Hoerrner L, Hutchinson N, et al.
J Clin Invest
. 1997 Jul;
100(1):93-106.
PMID: 9202061
To examine the activity of matrix metalloproteinases (MMPs) and aggrecanase in control and diseased human articular cartilage, metabolic fragments of aggrecan were detected with monospecific antipeptide antibodies. The distribution and...
4.
Calaycay J, Kelly T, MacNaul K, McCauley E, Qi H, Grant S, et al.
J Biol Chem
. 1996 Nov;
271(45):28212-9.
PMID: 8910438
Recombinant human inducible nitric-oxide synthase (rH-iNOS) was expressed in the baculovirus system and purified by a novel immunoaffinity column. rH-iNOS and its native counterpart from cytokine-stimulated primary hepatocytes exhibited similar...
5.
Chabin R, McCauley E, Calaycay J, Kelly T, MacNaul K, Wolfe G, et al.
Biochemistry
. 1996 Jul;
35(29):9567-75.
PMID: 8755738
Nitric oxide synthase catalyzes the pyridine nucleotide-dependent oxidation of L-arginine to nitric oxide and L-citrulline. It is a specialized cytochrome P450 monooxygenase that is sensitive to inhibition by imidazole. Steady-state...
6.
Yao J, Glant T, Lark M, Mikecz K, Jacobs J, Hutchinson N, et al.
J Bone Miner Res
. 1995 Sep;
10(9):1417-27.
PMID: 7502715
Periprosthetic osteolysis with or without aseptic loosening is a major clinical problem in total hip arthroplasty. While the macrophage response to prosthetic wear debris and its role in periprosthetic osteolysis...
7.
Hom G, Grant S, Wolfe G, Bach T, Macintyre D, Hutchinson N
J Pharmacol Exp Ther
. 1995 Jan;
272(1):452-9.
PMID: 7529313
The role of inducible nitric oxide synthase (iNOS) was examined in the hypotension and vascular hyporesponsiveness to norepinephrine (NE) invoked by lipopolysaccharide (LPS) in pentobarbital-anesthetized rats. Saline, dexamethasone (DEX), NG-monomethyl-L-arginine...
8.
Lark M, MacNaul K, Donatelli S, McDonnell J, Hoerrner L, STEVENS K, et al.
J Rheumatol
. 1994 Sep;
21(9):1716-24.
PMID: 7799356
Objective: To study the effects of the intraarticular injection of canine monocyte conditioned medium (cMCM) into dogs on proteoglycan fragment and stromelysin levels in the joint. Methods: cMCM was injected...
9.
Chartrain N, Geller D, Koty P, Sitrin N, Nussler A, Hoffman E, et al.
J Biol Chem
. 1994 Mar;
269(9):6765-72.
PMID: 7509810
Nitric oxide, a multifunctional effector molecule synthesized by nitric oxide synthase (NOS) from L-arginine, conveys signals for vasorelaxation, neurotransmission, and cytotoxicity. Three different NOS isoforms have been identified which fall...
10.
MacNaul K, Hutchinson N
Biochem Biophys Res Commun
. 1993 Nov;
196(3):1330-4.
PMID: 7504476
To examine the potential contribution of endothelial cell cNOS (ec-cNOS) and inducible NOS (iNOS) in controlling vascular tone under normal versus inflammatory conditions, we performed Northern hybridizations to examine the...