N Defer
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Explore the profile of N Defer including associated specialties, affiliations and a list of published articles.
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67
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811
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Recent Articles
1.
Adamy C, Le Corvoisier P, Candiani G, Kirsch M, Pavoine C, Defer N, et al.
Arch Mal Coeur Vaiss
. 2005 Oct;
98(9):906-12.
PMID: 16231578
The pro-inflammatory cytokine, tumor necrosis factor alpha (TNF alpha), in concert with neurohormones, contributes to chronic heart failure (CHF) progression. This implies that TNF a antagonism may constitute an important...
2.
Hanoune J, Defer N
Annu Rev Pharmacol Toxicol
. 2001 Mar;
41:145-74.
PMID: 11264454
At least nine closely related isoforms of adenylyl cyclases (ACs), the enzymes responsible for the synthesis of cyclic AMP (cAMP) from ATP, have been cloned and characterized in mammals. Depending...
3.
Vanvooren V, Allgeier A, Cosson E, Van Sande J, Defer N, Pirlot M, et al.
Mol Cell Endocrinol
. 2001 Feb;
170(1-2):185-96.
PMID: 11162902
Although the TSH receptor and Galpha(s), which activate the cAMP cascade in the thyroid gland have been much studied, nothing is known about the adenylyl cyclase (AC) isoforms which are...
4.
Defer N, Hanoune J
Am J Physiol Renal Physiol
. 2000 Sep;
279(3):F400-16.
PMID: 10966920
The present review focuses on the potential physiological regulations involving different isoforms of adenylyl cyclase (AC), the enzymatic activity responsible for the synthesis of cAMP from ATP. Depending on the...
5.
Lipskaia L, Defer N, Esposito G, Hajar I, Garel M, Rockman H, et al.
Circ Res
. 2000 Apr;
86(7):795-801.
PMID: 10764414
The predominant functional adenylyl cyclases normally expressed in cardiac tissue and coupled to beta-adrenergic receptors are inhibited by micromolar Ca(2+) concentration. To modify the overall balance of activities, we have...
6.
Tzavara E, Valjent E, Firmo C, Mas M, Beslot F, Defer N, et al.
Eur J Neurosci
. 2000 Apr;
12(3):1038-46.
PMID: 10762335
Region-specific up-regulation of the cyclic AMP pathway is considered an important molecular mechanism in the origin of the somatic manifestations of the withdrawal syndrome to known drugs of abuse. Nevertheless,...
7.
Mamluk R, Defer N, Hanoune J, Meidan R
Endocrinology
. 1999 Sep;
140(10):4601-8.
PMID: 10499516
The involvement of cAMP in various aspects of ovarian steroidogenic cells functions has been extensively studied. However, the adenylyl cyclase (AC) types expressed in ovarian cells, of any species, are...
8.
Espinasse I, Iourgenko V, Richer C, Heimburger M, Defer N, Bourin M, et al.
Cardiovasc Res
. 1999 Aug;
42(1):87-98.
PMID: 10434999
Objective: To address the effect of longstanding left ventricular (LV) hypertrophy and failure on LV adenylyl cyclase (AC) gene expression, mRNA concentrations of the main cardiac AC isoforms were measured...
9.
Lipskaia L, Grepin C, Defer N, Hanoune J
J Cell Physiol
. 1998 Jun;
176(1):50-6.
PMID: 9618144
DMSO-primed P19 pluripotent cells, which recapitulate the first stages of mammalian cardiogenesis and endodermal formation, were used as an in vitro model to analyze the variations in activity and expression...
10.
Suzuki Y, Shen T, Poyard M, Hanoune J, Defer N
Am J Physiol
. 1998 Jun;
274(6):C1674-85.
PMID: 9611134
Changes in the activity and in the expression of adenylyl cyclase (AC) were examined in mouse skeletal muscle after denervation and during development. Four isoforms of AC (AC2, AC6, AC7,...