N D Ridgway
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Explore the profile of N D Ridgway including associated specialties, affiliations and a list of published articles.
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48
Citations
784
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Recent Articles
1.
Sunohara J, Ridgway N, Cook H, Byers D
J Neurochem
. 2001 Aug;
78(3):664-72.
PMID: 11483670
Myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP) have been implicated in membrane-cytoskeletal events underlying cell adhesion, migration, secretion, and phagocytosis. In BV-2 microglial cells, lipopolysaccharide (LPS) elicited...
2.
Mohammadi A, Perry R, Storey M, Cook H, Byers D, Ridgway N
J Lipid Res
. 2001 Jul;
42(7):1062-71.
PMID: 11441133
Oxysterol binding protein (OSBP) translocation between Golgi and vesicular/cytoplasmic compartments is affected by conditions that alter cholesterol and sphingomyelin homeostasis, indicating a role in lipid and sterol regulation in this...
3.
Wright M, Henneberry A, Lagace T, Ridgway N, McMaster C
J Biol Chem
. 2001 Apr;
276(27):25254-61.
PMID: 11306571
Genetic inactivation of the synthesis of phosphatidylcholine, the most abundant membrane lipid in eukaryotic cells, induces apoptosis. Administration of farnesol, a catabolite within the isoprenoid/cholesterol pathway, also induces apoptosis. The...
4.
Xu Y, Liu Y, Ridgway N, McMaster C
J Biol Chem
. 2001 Mar;
276(21):18407-14.
PMID: 11279184
Oxysterol-binding proteins (OSBPs) are a family of eukaryotic intracellular lipid receptors. Mammalian OSBP1 binds oxygenated derivatives of cholesterol and mediates sterol and phospholipid synthesis through as yet poorly undefined mechanisms....
5.
Henneberry A, Lagace T, Ridgway N, McMaster C
Mol Biol Cell
. 2001 Mar;
12(3):511-20.
PMID: 11251067
Phosphatidylcholine and phosphatidylethanolamine are the most abundant phospholipids in eukaryotic cells and thus have major roles in the formation and maintenance of vesicular membranes. In yeast, diacylglycerol accepts a phosphocholine...
6.
Yu A, Byers D, Ridgway N, McMaster C, Cook H
Biochim Biophys Acta
. 2000 Oct;
1487(2-3):296-308.
PMID: 11018481
Externalization of phosphatidylserine (PtdSer) is a common feature of programmed cell death and plays an important role in the recognition and removal of apoptotic cells. In this study with U937...
7.
Lagace T, Storey M, Ridgway N
J Biol Chem
. 2000 May;
275(19):14367-74.
PMID: 10799518
Sterol regulation-defective (SRD) 4 cells expressing a mutant sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP D443N) and Chinese hamster ovary (CHO) cells stably expressing SCAP (CHO-SCAP) and SCAP D443N...
8.
Ridgway N, Byers D, Cook H, Storey M
Prog Lipid Res
. 2000 May;
38(4):337-60.
PMID: 10793888
The lethal consequences of imbalances in lipid and sterol metabolism in human diseases such as atherosclerosis and lipid storage disorders underscores our need to know how cholesterol, phospholipid and sphingolipid...
9.
Ridgway N
Biochim Biophys Acta
. 2000 Apr;
1484(2-3):129-41.
PMID: 10760463
There is ample evidence from experimental models and human metabolic disorders indicating that cholesterol and sphingomyelin (SM) levels are coordinately regulated. Generally it has been observed that altering the cellular...
10.
Zhang J, Ming L, Sjovall J, Cook H, Ridgway N, Byers D
J Steroid Biochem Mol Biol
. 2000 Jan;
70(4-6):123-31.
PMID: 10622400
Progesterone inhibits intracellular transport of lysosomal cholesterol in cultured cells, and thus at least in part mimics the biochemical phenotype of Niemann-Pick type C disease (NPC) in human fibroblasts. The...