Myong-Jung Kim
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Explore the profile of Myong-Jung Kim including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
339
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0
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Recent Articles
1.
Enzyme-assisted high throughput sequencing of an expanded genetic alphabet at single base resolution
Wang B, Bradley K, Kim M, Laos R, Chen C, Gerloff D, et al.
Nat Commun
. 2024 May;
15(1):4057.
PMID: 38744910
With just four building blocks, low sequence information density, few functional groups, poor control over folding, and difficulties in forming compact folds, natural DNA and RNA have been disappointing platforms...
2.
Enzyme-Assisted High Throughput Sequencing of an Expanded Genetic Alphabet at Single Base Resolution
Wang B, Bradley K, Kim M, Laos R, Chen C, Gerloff D, et al.
Res Sq
. 2024 Jan;
PMID: 38196584
Many efforts have sought to apply laboratory evolution (LIVE) to natural nucleic acid (NA) scaffolds to directly evolve functional molecules. However, synthetic biology can move beyond natural NA scaffolds to...
3.
Kawabe H, Thomas C, Hoshika S, Kim M, Kim M, Miessner L, et al.
Nat Commun
. 2023 Oct;
14(1):6820.
PMID: 37884513
The 4-letter DNA alphabet (A, T, G, C) as found in Nature is an elegant, yet non-exhaustive solution to the problem of storage, transfer, and evolution of biological information. Here,...
4.
Li Y, Abraham C, Suslov O, Yaren O, Shaw R, Kim M, et al.
ACS Synth Biol
. 2023 May;
12(6):1772-1781.
PMID: 37227319
One horizon in synthetic biology seeks alternative forms of DNA that store, transcribe, and support the evolution of biological information. Here, hydrogen bond donor and acceptor groups are rearranged within...
5.
Hoshika S, Leal N, Kim M, Kim M, Karalkar N, Kim H, et al.
Science
. 2019 Feb;
363(6429):884-887.
PMID: 30792304
We report DNA- and RNA-like systems built from eight nucleotide "letters" (hence the name "hachimoji") that form four orthogonal pairs. These synthetic systems meet the structural requirements needed to support...
6.
Hoshika S, Singh I, Switzer C, Molt Jr R, Leal N, Kim M, et al.
J Am Chem Soc
. 2018 Aug;
140(37):11655-11660.
PMID: 30148365
According to the iconic model, the Watson-Crick double helix exploits nucleobase pairs that are both size complementary (big purines pair with small pyrimidines) and hydrogen bond complementary (hydrogen bond donors...
7.
Singh I, Kim M, Molt R, Hoshika S, Benner S, Georgiadis M
ACS Synth Biol
. 2017 Jul;
6(11):2118-2129.
PMID: 28752992
A goal of synthetic biology is to develop new nucleobases that retain the desirable properties of natural nucleobases at the same time as expanding the genetic alphabet. The nonstandard Watson-Crick...
8.
Wang X, Hoshika S, Peterson R, Kim M, Benner S, Kahn J
ACS Synth Biol
. 2017 Jan;
6(5):782-792.
PMID: 28094993
Synthetic nucleobases presenting non-Watson-Crick arrangements of hydrogen bond donor and acceptor groups can form additional nucleotide pairs that stabilize duplex DNA independent of the standard A:T and G:C pairs. The...
9.
Matsuura M, Winiger C, Shaw R, Kim M, Kim M, Daugherty A, et al.
ACS Synth Biol
. 2016 Dec;
6(3):388-394.
PMID: 27935283
Deoxynucleoside kinase from D. melanogaster (DmdNK) has broad specificity; although it catalyzes the phosphorylation of natural pyrimidine more efficiently than natural purine nucleosides, it accepts all four 2'-deoxynucleosides and many...
10.
Winiger C, Shaw R, Kim M, Moses J, Matsuura M, Benner S
ACS Synth Biol
. 2016 Sep;
6(2):194-200.
PMID: 27648724
2,4-Diaminopyrimidine (trivially K) and imidazo[1,2-a]-1,3,5-triazine-2(8H)-4(3H)-dione (trivially X) form a nucleobase pair with Watson-Crick geometry as part of an artificially expanded genetic information system (AEGIS). Neither K nor X can form...