Myong-Chul Koag
Overview
Explore the profile of Myong-Chul Koag including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
480
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0
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Recent Articles
1.
Schmaltz L, Koag M, Kou Y, Zhang L, Lee S
Biochem J
. 2023 Apr;
480(9):573-585.
PMID: 37078496
Various alkylating agents are known to preferentially modify guanine in DNA, resulting in the formation of N7-alkylguanine (N7-alkylG) and the imidazole ring opened alkyl-formamidopyrimidine (alkyl-FapyG) lesions. Evaluating the mutagenic effects...
2.
Rozelle A, Cheun Y, Vilas C, Koag M, Lee S
Nat Commun
. 2021 Mar;
12(1):1897.
PMID: 33772030
Oxidative damage to DNA generates 7,8-dihydro-8-oxoguanine (oxoG) and 7,8-dihydro-8-oxoadenine (oxoA) as two major lesions. Despite the comparable prevalence of these lesions, the biological effects of oxoA remain poorly characterized. Here...
3.
Ouzon-Shubeita H, Jung H, Lee M, Koag M, Lee S
Biochem J
. 2020 Apr;
477(9):1601-1612.
PMID: 32297632
Thymine:guanine base pairs are major promutagenic mismatches occurring in DNA metabolism. If left unrepaired, these mispairs can cause C to T transition mutations. In humans, T:G mismatches are repaired in...
4.
Koag M, Jung H, Lee S
Nucleic Acids Res
. 2020 Apr;
48(9):5119-5134.
PMID: 32282906
Reactive oxygen species generate the genotoxic 8-oxoguanine (oxoG) and 8-oxoadenine (oxoA) as major oxidative lesions. The mutagenicity of oxoG is attributed to the lesion's ability to evade the geometric discrimination...
5.
Koag M, Jung H, Kou Y, Lee S
Molecules
. 2019 Nov;
24(21).
PMID: 31683505
A wide range of endogenous and exogenous alkylating agents attack DNA to generate various alkylation adducts. N7-methyl-2-deoxyguanosine (Fm7dG) is the most abundant alkylative DNA lesion. If not repaired, Fm7dG can...
6.
Kou Y, Koag M, Lee S
Molecules
. 2019 Oct;
24(19).
PMID: 31569643
Chronic inflammation is closely associated with cancer development. One possible mechanism for inflammation-induced carcinogenesis is DNA damage caused by reactive halogen species, such as hypochlorous acid, which is released by...
7.
Koag M, Jung H, Lee S
J Am Chem Soc
. 2019 Mar;
141(11):4584-4596.
PMID: 30817143
Reactive oxygen species attack DNA to produce 7,8-dihyro-8-oxoguanine (oxoG) and 7,8-dihydro-8-oxoadenine (oxoA) as major lesions. The structural basis for the mutagenicity of oxoG, which induces G to T mutations, is...
8.
Ouzon-Shubeita H, Baker M, Koag M, Lee S
Biochem J
. 2019 Feb;
476(4):747-758.
PMID: 30709915
Oxaliplatin, together with cisplatin, is among the most important drugs used in cancer chemotherapy. Oxaliplatin, which contains a bulky diaminocyclohexane (DACH) moiety, kills cancer cells mainly by producing (DACH)Pt-GpG intrastrand...
9.
Kou Y, Koag M, Lee S
Biochemistry
. 2018 Jun;
57(34):5105-5116.
PMID: 29957995
A wide variety of endogenous and exogenous alkylating agents attack DNA to preferentially generate N7-alkylguanine (N7-alkylG) adducts. Studies of the effect of N7-alkylG lesions on biological processes have been difficult...
10.
Koag M, Lee S
Biochem J
. 2018 Jan;
475(3):571-585.
PMID: 29301983
DNA polymerases accommodate various base-pair conformations in the event of incorrect insertions. In particular, Watson-Crick-like dG:dTTP base pair has been observed at the insertion site of human DNA polymerase β...