Kirill Tsirulnikov
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Explore the profile of Kirill Tsirulnikov including associated specialties, affiliations and a list of published articles.
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11
Citations
129
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Recent Articles
1.
Zhekova H, Jiang J, Wang W, Tsirulnikov K, Kayik G, Khan H, et al.
Commun Biol
. 2022 Dec;
5(1):1372.
PMID: 36517642
Anion exchanger 1 (AE1, band 3) is a major membrane protein of red blood cells and plays a key role in acid-base homeostasis, urine acidification, red blood cell shape regulation,...
2.
Wang W, Tsirulnikov K, Zhekova H, Kayik G, Khan H, Azimov R, et al.
Nat Commun
. 2021 Oct;
12(1):6083.
PMID: 34645810
No abstract available.
3.
Wang W, Tsirulnikov K, Zhekova H, Kayik G, Khan H, Azimov R, et al.
Nat Commun
. 2021 Sep;
12(1):5690.
PMID: 34584093
SLC4 transporters play significant roles in pH regulation and cellular sodium transport. The previously solved structures of the outward facing (OF) conformation for AE1 (SLC4A1) and NBCe1 (SLC4A4) transporters revealed...
4.
Huynh K, Jiang J, Abuladze N, Tsirulnikov K, Kao L, Shao X, et al.
Nat Commun
. 2018 Mar;
9(1):900.
PMID: 29500354
Na-coupled acid-base transporters play essential roles in human biology. Their dysfunction has been linked to cancer, heart, and brain disease. High-resolution structures of mammalian Na-coupled acid-base transporters are not available....
5.
Tsirulnikov K, Duarte S, Ray A, Datta N, Zarrinpar A, Hwang L, et al.
J Cancer
. 2018 Jan;
9(1):1-12.
PMID: 29290764
Ras proteins (HRas, KRas and NRas) are common oncogenes that require membrane association for activation. Previous approaches to block/inhibit Ras membrane association were unsuccessful for cancer treatment in human clinical...
6.
Jiang J, Magilnick N, Tsirulnikov K, Abuladze N, Atanasov I, Ge P, et al.
PLoS One
. 2013 Feb;
8(2):e55408.
PMID: 23393575
Anion exchanger 1 (AE1) is the major erythrocyte membrane protein that mediates chloride/bicarbonate exchange across the erythrocyte membrane facilitating CO₂ transport by the blood, and anchors the plasma membrane to...
7.
Tsirulnikov K, Abuladze N, Vahi R, Hasnain H, Phillips M, Ryan C, et al.
FEBS Lett
. 2012 Sep;
586(21):3799-804.
PMID: 23010594
Aminoacylase 3 (AA3) mediates deacetylation of N-acetyl aromatic amino acids and mercapturic acids. Deacetylation of mercapturic acids of exo- and endobiotics are likely involved in their toxicity. AA3 is predominantly...
8.
Tsirulnikov K, Abuladze N, Bragin A, Faull K, Cascio D, Damoiseaux R, et al.
Toxicol Appl Pharmacol
. 2012 Jul;
263(3):303-14.
PMID: 22819785
4-Hydroxy-2-nonenal (4HNE) and acrolein (ACR) are highly reactive neurotoxic products of lipid peroxidation that are implicated in the pathogenesis and progression of Alzheimer's and Parkinson's diseases. Conjugation with glutathione (GSH)...
9.
Hsieh J, Tsirulnikov K, Sawaya M, Magilnick N, Abuladze N, Kurtz I, et al.
Proc Natl Acad Sci U S A
. 2010 Oct;
107(42):17962-7.
PMID: 20921362
Trichloroethylene (TCE) is one of the most widespread environmental contaminants, which is metabolized to N-acetyl-S-1,2-dichlorovinyl-L-cysteine (NA-DCVC) before being excreted in the urine. Alternatively, NA-DCVC can be deacetylated by aminoacylase 3...
10.
Tsirulnikov K, Abuladze N, Koag M, Newman D, Scholz K, Bondar G, et al.
Toxicol Appl Pharmacol
. 2010 Jan;
244(2):218-25.
PMID: 20060011
N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine (Ac-DCVC) and S-(1,2-dichlorovinyl)-l-cysteine (DCVC) are the glutathione conjugation pathway metabolites of a common industrial contaminant and potent nephrotoxicant trichloroethylene (TCE). Ac-DCVC and DCVC are accumulated in the renal proximal...