Mutsuo Sekiguchi
Overview
Explore the profile of Mutsuo Sekiguchi including associated specialties, affiliations and a list of published articles.
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59
Citations
1232
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Recent Articles
1.
Oka S, Tsuzuki T, Hidaka M, Ohno M, Nakatsu Y, Sekiguchi M
Cell Death Discov
. 2022 Apr;
8(1):150.
PMID: 35365611
Oxidative stress plays a pivotal role in the differentiation and proliferation of cells and programmed cell death. However, studies on the role of oxidative stress in differentiation have mainly employed...
2.
Ishii T, Igawa T, Hayakawa H, Fujita T, Sekiguchi M, Nakabeppu Y
J Biol Chem
. 2021 Nov;
297(6):101447.
PMID: 34839120
No abstract available.
3.
Ishii T, Igawa T, Hayakawa H, Fujita T, Sekiguchi M, Nakabeppu Y
J Biol Chem
. 2020 Jul;
295(34):12247-12261.
PMID: 32647012
PCBP1, a member of the poly(C)-binding protein (PCBP) family, has the capability of binding heavily oxidized RNA and therefore participates in the cellular response to oxidative conditions, helping to induce...
4.
Takeishi Y, Fujikane R, Rikitake M, Obayashi Y, Sekiguchi M, Hidaka M
J Biol Chem
. 2019 Dec;
295(4):1056-1065.
PMID: 31843968
The mismatch repair (MMR) complex is composed of MutSα (MSH2-MSH6) and MutLα (MLH1-PMS2) and specifically recognizes mismatched bases during DNA replication. -Methylguanine is produced by treatment with alkylating agents, such...
5.
Ishii T, Sekiguchi M
DNA Repair (Amst)
. 2019 Jul;
81:102666.
PMID: 31326364
Reactive oxygen species (ROS) are produced during normal cellular metabolism, and various oxidized compounds are formed by the ROS attack. Among oxidized bases, 8-oxo-7,8-dihydroguanine (8-oxoG) is most abundant and seems...
6.
Oka S, Hayashi M, Taguchi K, Hidaka M, Tsuzuki T, Sekiguchi M
Carcinogenesis
. 2019 May;
41(1):36-43.
PMID: 31058919
Reactive oxygen species (ROS) generated during cellular respiration oxidize various cellular constituents, which cause carcinogenesis. Because most studies on the role of ROS in carcinogenesis have mainly been performed using...
7.
Ishii T, Hayakawa H, Igawa T, Sekiguchi T, Sekiguchi M
Proc Natl Acad Sci U S A
. 2018 Jun;
115(26):6715-6720.
PMID: 29891675
In aerobically growing cells, the guanine base of RNA is oxidized to 8-oxo-7,8-dihydroguanine (8-oxoG), which induces alteration in their gene expression. We previously demonstrated that the human AUF1 protein binds...
8.
Dai D, Gan W, Hayakawa H, Zhu J, Zhang X, Hu G, et al.
Proc Natl Acad Sci U S A
. 2018 Apr;
115(16):4218-4222.
PMID: 29610342
Reactive oxygen species formed within the mammalian cell can produce 8-oxo-7,8-dihydroguanine (8-oxoG) in mRNA, which can cause base mispairing during gene expression. Here we found that administration of 8-oxoGTP in...
9.
Hashiguchi K, Hayashi M, Sekiguchi M, Umezu K
Mutat Res
. 2018 Feb;
808:10-19.
PMID: 29482072
The hydrolysis of nucleotides containing 8-oxo-7,8-dihydroguanine (8-oxoG) is important in the maintenance of genome stability. Human cells possess three types of proteins, MTH1 (NUDT1), MTH2 (NUDT15) and MTH3 (NUDT18), which...
10.
Li J, Yang C, Tian X, Li Y, Cui J, Chen Z, et al.
Oncotarget
. 2017 Dec;
8(62):105714-105726.
PMID: 29285286
Background: MutT-related proteins, including MTH1, MTH2, MTH3 and NUDT5, can effectively degrade 8-oxoGua-containing nucleotides. The MTH1 expression is elevated in many types of human tumors and MTH1 overexpression correlates with...