Jian-Ping Cai
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Explore the profile of Jian-Ping Cai including associated specialties, affiliations and a list of published articles.
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163
Citations
1343
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Recent Articles
1.
Gao X, Li S, Cai J
J Gerontol A Biol Sci Med Sci
. 2025 Mar;
PMID: 40089807
The aging of the population is a global concern. In the post-COVID-19 pandemic era, there are no effective methods to identify aging acceleration due to infection. In this study, we...
2.
Wang C, Zhang M, Xu Y, Hu G, Cai J, Lan T, et al.
Biomed Chromatogr
. 2024 Dec;
39(1):e6056.
PMID: 39628091
In hepatic drug metabolism, cytochrome P450 (CYP450) enzymes, particularly CYP3A4, catalyze the majority of drug biotransformations, accounting for over 50% of the CYP450 family's metabolic capacity. This study aimed to...
3.
Zhong Y, Kong Q, Wang J, Ye F, Li X, Zhang L, et al.
Chem Res Toxicol
. 2024 Oct;
37(11):1903-1910.
PMID: 39433447
Cytochrome P450 2D6 (CYP2D6) exhibits rich genetic polymorphism, and functional changes caused by variations are the key reasons for differences in substrate drug systemic exposure. Discovering novel variants and defining...
4.
Chen J, Hu Y, Hu J, Ye Z, Lin Q, Cai J, et al.
Biomed Pharmacother
. 2024 Oct;
180:117511.
PMID: 39366029
The aim of this study was to investigate the catalytic activity of 26 Cytochrome P450 3A4 (CYP3A4) variants and drug interactions on imatinib metabolism in recombinant insect microsomes. This study...
5.
Bao S, Tang P, Zhou Q, Shao C, Xiao Z, Cheng C, et al.
Expert Opin Drug Metab Toxicol
. 2024 Sep;
21(1):95-103.
PMID: 39316645
Background: The gene polymorphisms of the CYP2C9, as well as the substrate specificity of the enzyme, result in different clearances for different substrates by CYP2C9 variants. Research Designand Methods: The...
6.
Liu Y, Pang J, Zhang C, Zeng L, Wang Y, Wang S, et al.
Heliyon
. 2024 Sep;
10(17):e36574.
PMID: 39263169
Background: Glycoprotein non-metastatic melanoma B (GPNMB)/osteoactivin was first identified in the human melanoma cell lines. GPNMB plays a key role in the anti-inflammatory and antioxidative functions as well as osteoblast...
7.
Hu Y, Ye Z, Wu H, Chen X, Xia H, Cai J, et al.
Chem Biol Interact
. 2024 Jul;
399:111154.
PMID: 39025286
Clothianidin, classified as a second-generation neonicotinoid, has achieved extensive application due to its high efficacy against insect pests. This broad-spectrum usage has resulted in its frequent detection in environmental surveys....
8.
Wang J, Xu X, Li X, Luo J, Zhang Z, Chen J, et al.
Toxicol Appl Pharmacol
. 2024 Jun;
489:117016.
PMID: 38925514
To elucidate the impact of CYP3A4 activity inhibition and genetic polymorphism on the metabolism of crizotinib. Enzymatic incubation systems for crizotinib were established, and Sprague-Dawley rats were utilized for in...
9.
Li S, Gao X, Wang Z, Li J, Zeng L, Dang Y, et al.
Epigenomics
. 2024 Jun;
16(10):715-731.
PMID: 38869474
Liquid biopsies analyzing cell-free DNA (cfDNA) methylation in plasma offer a noninvasive diagnostic for diseases, with the potential of aging biomarkers underexplored. Utilizing enzymatic methyl-seq (EM-seq), this study assessed cfDNA...
10.
Chen H, Wang Q, Qi R, Cai J
Front Cardiovasc Med
. 2024 May;
11:1384679.
PMID: 38807946
Background: Platelet hyperreactivity is a risk factor for thrombosis in elderly patients with cardiovascular diseases. However, the mechanism of platelet hyperactivation has not been elucidated. This study aims to investigate...