Muneyoshi Okada
Overview
Explore the profile of Muneyoshi Okada including associated specialties, affiliations and a list of published articles.
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Articles
116
Citations
1395
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Recent Articles
1.
Kodama T, Kameshima S, Otani K, Okada M, Yamawaki H
Br J Pharmacol
. 2025 Jan;
182(8):1823-1835.
PMID: 39842419
Background And Purpose: Eukaryotic elongation factor 2 kinase (eEF2K) belongs to the Ca/calmodulin-dependent protein kinase family. We previously revealed that A484954, a selective eEF2K inhibitor, caused hypotensive and diuretic effects...
2.
Niijima R, Otani K, Kodama T, Okada M, Yamawaki H
J Pharmacol Sci
. 2024 Dec;
157(1):39-44.
PMID: 39706644
Pulmonary hypertension (PH) is a progressive disease with a poor prognosis in which high pulmonary artery pressure leads to right heart failure, therefore, there is an urgent need to elucidate...
3.
Otani K, Uemura N, Funada H, Kodama T, Okada M, Yamawaki H
J Pharmacol Sci
. 2024 Jul;
156(1):38-44.
PMID: 39068033
Obesity and diabetes are major risk factors for cardiovascular diseases. Zucker fatty diabetes mellitus (ZFDM) rats are novel animal model of obesity and type 2 diabetes. We have recently reported...
4.
Okamura Y, Adachi K, Niijima R, Kodama T, Otani K, Okada M, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2023 Nov;
397(5):3379-3387.
PMID: 37955693
Purpose: Hypertension is one of the major risk factors for renal failure and cardiovascular diseases, and is caused by various abnormalities including the contractility of blood vessels. Otsuka Long-Evans Tokushima...
5.
Kodama T, Otani K, Okada M, Yamawaki H
J Vet Med Sci
. 2023 Oct;
85(12):1314-1318.
PMID: 37853639
Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) is a protein kinase that inactivates eEF2, a protein that mediates a peptidyl-tRNA translocation during an elongation step of protein synthesis. We have...
6.
Fujioka Y, Otani K, Kodama T, Okada M, Yamawaki H
J Vet Med Sci
. 2023 Oct;
85(11):1157-1164.
PMID: 37779091
Cellular senescence is a highly stable state associated with cell cycle arrest, that is elicited in response to various stresses. The accumulation of senescent cells in tissues drives age-related diseases....
7.
Okamura Y, Niijima R, Kameshima S, Kodama T, Otani K, Okada M, et al.
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36835249
Hypertension is one of the major risk factors for cardiovascular diseases and is caused by various abnormalities including the contractility of blood vessels. Spontaneously hypertensive rats (SHR), whose systemic blood...
8.
Yamamoto A, Kodama T, Otani K, Okada M, Yamawaki H
J Vet Med Sci
. 2022 Aug;
84(10):1352-1357.
PMID: 35934798
Chemerin is an adipocytokine whose concentration in blood correlates positively with blood pressure (BP). We have recently revealed that acute intracerebroventricular (i.c.v.) injection of chemerin-9, an active fragment of human...
9.
Kodama T, Otani K, Okada M, Yamawaki H
Eur J Pharmacol
. 2022 May;
926:175042.
PMID: 35598844
Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) repressively regulates protein translation through phosphorylating eEF2. We previously showed that expression and activity of eEF2K are increased in isolated mesenteric arteries from...
10.
Otani K, Funada H, Teranishi R, Okada M, Yamawaki H
Int J Mol Sci
. 2022 Apr;
23(8).
PMID: 35457048
Zucker fatty diabetes mellitus (ZFDM) rats harboring the missense mutation (fa) in a leptin receptor gene have been recently established as a novel animal model of obesity and type 2...