» Authors » Muhsen Al-Dhalimy

Muhsen Al-Dhalimy

Explore the profile of Muhsen Al-Dhalimy including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 11
Citations 1206
Followers 0
Related Specialties
Top 10 Co-Authors
Published In
Affiliations
Soon will be listed here.
Recent Articles
1.
Zhang Q, Tang W, Deater M, Phan N, Marcogliese A, Li H, et al.
Blood . 2016 Oct; 128(24):2774-2784. PMID: 27756748
Fanconi anemia (FA) is an inherited bone marrow failure disorder associated with a high incidence of leukemia and solid tumors. Bone marrow transplantation is currently the only curative therapy for...
2.
Garbati M, Hays L, Rathbun R, Jillette N, Chin K, Al-Dhalimy M, et al.
J Leukoc Biol . 2015 Oct; 99(3):455-65. PMID: 26432900
The Fanconi anemia proteins participate in a canonical pathway that repairs cross-linking agent-induced DNA damage. Cells with inactivated Fanconi anemia genes are universally hypersensitive to such agents. Fanconi anemia-deficient hematopoietic...
3.
Hejna J, Holtorf M, Hines J, Mathewson L, Hemphill A, Al-Dhalimy M, et al.
J Biol Chem . 2008 Feb; 283(15):9844-51. PMID: 18263878
The disease Fanconi anemia is a genome instability syndrome characterized by cellular sensitivity to DNA interstrand cross-linking agents, manifest by decreased cellular survival and chromosomal aberrations after such treatment. There...
4.
Azuma H, Paulk N, Ranade A, Dorrell C, Al-Dhalimy M, Ellis E, et al.
Nat Biotechnol . 2007 Aug; 25(8):903-10. PMID: 17664939
Mice that could be highly repopulated with human hepatocytes would have many potential uses in drug development and research applications. The best available model of liver humanization, the uroplasminogen-activator transgenic...
5.
Held P, Al-Dhalimy M, Willenbring H, Akkari Y, Jiang S, Torimaru Y, et al.
Mol Ther . 2005 Oct; 13(1):49-58. PMID: 16216560
Repopulation by transplanted cells can result in effective therapy for several regenerative organs including blood, liver, and skin. In contrast, cell therapies for renal diseases are not currently available. Here...
6.
Hamman K, Clark H, Montini E, Al-Dhalimy M, Grompe M, Finegold M, et al.
Mol Ther . 2005 Jul; 12(2):337-44. PMID: 16043102
Phenylalanine homeostasis in mammals is primarily controlled by liver phenylalanine hydroxylase (PAH) activity. Inherited PAH deficiency (phenylketonuria or PKU) leads to hyperphenylalaninemia in both mice and humans. A low level...
7.
Vogel A, van den Berg I, Al-Dhalimy M, Groopman J, Ou C, Ryabinina O, et al.
Hepatology . 2004 Feb; 39(2):433-43. PMID: 14767996
The murine model of hereditary tyrosinemia type 1 (HT1) was used to analyze the relationship between chronic liver disease and programmed cell death in vivo. In healthy fumarylacetoacetate hydrolase deficient...
8.
Wang X, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Grompe M
Proc Natl Acad Sci U S A . 2003 Aug; 100 Suppl 1:11881-8. PMID: 12902545
The appearance of bipotential oval cells in chronic liver injury suggests the existence of hepatocyte progenitor/stem cells. To study the origin and properties of this cell population, oval cell proliferation...
9.
Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, et al.
Nature . 2003 Apr; 422(6934):897-901. PMID: 12665832
Evidence suggests that haematopoietic stem cells might have unexpected developmental plasticity, highlighting therapeutic potential. For example, bone-marrow-derived hepatocytes can repopulate the liver of mice with fumarylacetoacetate hydrolase deficiency and correct...
10.
Montini E, Held P, Noll M, Morcinek N, Al-Dhalimy M, Finegold M, et al.
Mol Ther . 2002 Dec; 6(6):759-69. PMID: 12498772
Gene therapy applications of naked DNA constructs for genetic disorders have been limited because of lack of permanent transgene expression. This limitation, however, can be overcome by the Sleeping Beauty...