Mrinal Srivastava
Overview
Explore the profile of Mrinal Srivastava including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
1028
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Recent Articles
11.
Tang M, Feng X, Pei G, Srivastava M, Wang C, Chen Z, et al.
Cell Rep
. 2020 Aug;
32(6):108018.
PMID: 32783940
53BP1 plays a central role in dictating DNA repair choice between non-homologous end joining (NHEJ) and homologous recombination (HR), which is important for the sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPis)...
12.
Srivastava M, Su D, Zhang H, Chen Z, Tang M, Nie L, et al.
EMBO Rep
. 2020 Apr;
21(6):e49123.
PMID: 32307824
Replication across oxidative DNA lesions can give rise to mutations that pose a threat to genome integrity. How such lesions, which escape base excision repair, get removed without error during...
13.
The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks
Hu Q, Klages-Mundt N, Wang R, Lynn E, Kuma Saha L, Zhang H, et al.
Cell Rep
. 2020 Jan;
30(4):1235-1245.e4.
PMID: 31995761
DNA-protein crosslinks (DPCs) are a frequent form of DNA lesion and are strongly inhibitive in diverse DNA transactions. Despite recent developments, the biochemical detection of DPCs remains a limiting factor...
14.
Chen Z, Wang C, Jain A, Srivastava M, Tang M, Zhang H, et al.
Mol Cell Proteomics
. 2020 Jan;
19(3):467-477.
PMID: 31900314
Adenosine monophosphate-activated protein kinase (AMPK) is an obligate heterotrimer that consists of a catalytic subunit (α) and two regulatory subunits (β and γ). AMPK is a key enzyme in the...
15.
Zhang H, Chen Z, Ye Y, Ye Z, Cao D, Xiong Y, et al.
Nucleic Acids Res
. 2019 Sep;
47(19):10181-10201.
PMID: 31495888
Interstrand crosslinks (ICLs) are highly toxic DNA lesions that are repaired via a complex process requiring the coordination of several DNA repair pathways. Defects in ICL repair result in Fanconi...
16.
Chen Z, Lei C, Wang C, Li N, Srivastava M, Tang M, et al.
Nat Commun
. 2019 Jan;
10(1):104.
PMID: 30631047
AMP-activated protein kinase (AMPK) is a key regulator of cellular energy homeostasis. Although AMPK has been studied extensively in cellular processes, understanding of its substrates and downstream functional network, and...
17.
Srivastava M, Chen Z, Zhang H, Tang M, Wang C, Jung S, et al.
Cell Rep
. 2018 Dec;
25(13):3869-3883.e4.
PMID: 30590055
Eukaryotic cells use copious measures to ensure accurate duplication of the genome. Various genotoxic agents pose threats to the ongoing replication fork that, if not efficiently dealt with, can result...
18.
Wang C, Wang G, Feng X, Shepherd P, Zhang J, Tang M, et al.
Oncogene
. 2018 Dec;
38(14):2451-2463.
PMID: 30532030
Ataxia telangiectasia mutated and RAD3 related (ATR) protein kinase plays critical roles in ensuring DNA replication, DNA repair, and cell cycle control in response to replication stress, making ATR inhibition...
19.
Jung Y, Wang W, Jun S, Zhang J, Srivastava M, Kim M, et al.
Nat Cell Biol
. 2018 Oct;
20(11):1303-1314.
PMID: 30361697
Epithelial integrity is maintained by the cytoskeleton and through cell adhesion. However, it is not yet known how a deregulated cytoskeleton is associated with cancer. We identified cancer-related regulator of...
20.
Vartak S, Swarup H, Gopalakrishnan V, Gopinatha V, Ropars V, Nambiar M, et al.
FEBS J
. 2018 Sep;
285(21):3959-3976.
PMID: 30230716
Nonhomologous DNA end joining (NHEJ) is the major DNA double-strand break (DSB) repair pathway in mammals. Previously, we have described a small molecule inhibitor, SCR7, which can inhibit NHEJ in...