Moritz Weigl
Overview
Explore the profile of Moritz Weigl including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
1361
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Recent Articles
1.
Pradella D, Zhang M, Gao R, Yao M, Gluchowska K, Cendon-Florez Y, et al.
Nature
. 2024 Dec;
637(8047):955-964.
PMID: 39695225
Focal gene amplifications are among the most common cancer-associated mutations but have proven challenging to engineer in primary cells and model organisms. Here we describe a general strategy to engineer...
2.
Pultar M, Oesterreicher J, Hartmann J, Weigl M, Diendorfer A, Schimek K, et al.
J Extracell Biol
. 2024 Jun;
3(1):e134.
PMID: 38938681
Extracellular vesicles (EVs) are crucial mediators of cell-to-cell communication in physiological and pathological conditions. Specifically, EVs released from the vasculature into blood were found to be quantitatively and qualitatively different...
3.
Weigl M, Krammer T, Pultar M, Wieser M, Chaib S, Suda M, et al.
bioRxiv
. 2024 Apr;
PMID: 38645053
In the last decade cellular senescence, a hallmark of aging, has come into focus for pharmacologically targeting aging processes. Senolytics are one of these interventive strategies that have advanced into...
4.
Pradella D, Zhang M, Gao R, Yao M, Gluchowska K, Florez Y, et al.
bioRxiv
. 2023 Jul;
PMID: 37425909
Focal gene amplifications are among the most common cancer-associated mutations, but their evolution and contribution to tumorigenesis have proven challenging to recapitulate in primary cells and model organisms. Here we...
5.
Schanda J, Heher P, Weigl M, Drechsler S, Schadl B, Prueller J, et al.
Am J Sports Med
. 2022 Sep;
50(12):3355-3367.
PMID: 36053026
Background: Zoledronic acid improves bone microarchitecture and biomechanical properties after chronic rotator cuff repair (RCR) in rats. Besides the positive effects of zoledronic acid on bone mineral density and bone...
6.
Khamina K, Diendorfer A, Skalicky S, Weigl M, Pultar M, Krammer T, et al.
Int J Mol Sci
. 2022 Feb;
23(3).
PMID: 35163149
The plasma levels of tissue-specific microRNAs can be used as diagnostic, disease severity and prognostic biomarkers for chronic and acute diseases and drug-induced injury. Thereby, the combination of diverse microRNAs...
7.
Nunes A, Weigl M, Schneider A, Noureddine S, Yu L, Lahde C, et al.
Geroscience
. 2021 Nov;
44(1):503-518.
PMID: 34825304
MicroRNAs (miRNAs) are potent regulators of multiple biological processes. Previous studies have demonstrated that miR-146a-5p increases in normal mice during aging, while long-living Ames dwarf (df/df) mice maintain youthful levels...
8.
Lauterlein J, Gossiel F, Weigl M, Eastell R, Hackl M, Hermann P, et al.
JBMR Plus
. 2021 Sep;
5(9):e10534.
PMID: 34532618
Pathogenic variants in the Wnt-pathway co-receptor low-density lipoprotein (LDL) receptor-related protein 5 (LRP5) cause high bone mass (LRP5-HBM) due to insensitivity to the endogenous antagonist of Wnt-signaling. Although indicating incessant...
9.
Weigl M, Kocijan R, Ferguson J, Leinfellner G, Heimel P, Feichtinger X, et al.
J Bone Miner Res
. 2021 Feb;
36(6):1131-1144.
PMID: 33598975
MicroRNAs regulate bone homeostasis, and circulating microRNAs have been proposed as novel bone biomarkers. The effect of anti-osteoporotic treatment on circulating microRNAs has not been described in detail. Therefore, we...
10.
Saferding V, Hofmann M, Brunner J, Niederreiter B, Timmen M, Magilnick N, et al.
Aging Cell
. 2020 Oct;
19(11):e13244.
PMID: 33085187
Bone loss is one of the consequences of aging, leading to diseases such as osteoporosis and increased susceptibility to fragility fractures and therefore considerable morbidity and mortality in humans. Here,...