Monicah A Otieno
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Explore the profile of Monicah A Otieno including associated specialties, affiliations and a list of published articles.
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11
Citations
432
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Recent Articles
1.
Baudy A, Otieno M, Hewitt P, Gan J, Roth A, Keller D, et al.
Lab Chip
. 2019 Dec;
20(2):215-225.
PMID: 31799979
The liver is critical to consider during drug development because of its central role in the handling of xenobiotics, a process which often leads to localized and/or downstream tissue injury....
2.
Jang K, Otieno M, Ronxhi J, Lim H, Ewart L, Kodella K, et al.
Sci Transl Med
. 2019 Nov;
11(517).
PMID: 31694927
Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans, contributing to drug failures in...
3.
Holman N, Church R, Nautiyal M, Rose K, Thacker S, Otieno M, et al.
Toxicol Sci
. 2019 May;
170(2):499-508.
PMID: 31093666
Most idiosyncratic drug-induced liver injury appears to result from an adaptive immune attack on the liver. Recent evidence suggests that the T-cell response may be facilitated by the loss of...
4.
Barrile R, van der Meer A, Park H, Fraser J, Simic D, Teng F, et al.
Clin Pharmacol Ther
. 2018 Feb;
104(6):1240-1248.
PMID: 29484632
Clinical development of Hu5c8, a monoclonal antibody against CD40L intended for treatment of autoimmune disorders, was terminated due to unexpected thrombotic complications. These life-threatening side effects were not discovered during...
5.
Thacker S, Nautiyal M, Otieno M, Watkins P, Mosedale M
Toxicol Sci
. 2018 Feb;
163(1):92-100.
PMID: 29385596
Recent evidence supports that alterations in hepatocyte-derived exosomes (HDE) may play a role in the pathogenesis of drug-induced liver injury (DILI). HDE-based biomarkers also hold promise to improve the sensitivity...
6.
Letavic M, Savall B, Allison B, Aluisio L, Andres J, De Angelis M, et al.
J Med Chem
. 2017 May;
60(11):4559-4572.
PMID: 28493698
The synthesis and preclinical characterization of novel 4-(R)-methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridines that are potent and selective brain penetrant P2X7 antagonists are described. Optimization efforts based on previously disclosed unsubstituted 6,7-dihydro-4H-triazolo[4,5-c]pyridines, methyl substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazines,...
7.
Morgan S, Couch J, Guzzie-Peck P, Keller D, Kemper R, Otieno M, et al.
Toxicol Pathol
. 2017 Mar;
45(3):372-380.
PMID: 28351296
An Innovation and Quality (IQ) Consortium focus group conducted a cross-company survey to evaluate current practices and perceptions around the use of animal models of disease (AMDs) in nonclinical safety...
8.
Otieno M, Snoeys J, Lam W, Ghosh A, Player M, Pocai A, et al.
Toxicol Sci
. 2017 Feb;
163(2):374-384.
PMID: 28206647
TAK-875, a GPR40 agonist, was withdrawn from Phase III clinical trials due to drug-induced liver injury (DILI). Mechanistic studies were conducted to identify potential DILI hazards (covalent binding burden (CVB),...
9.
Otieno M, Bhaskaran V, Janovitz E, Callejas Y, Foster W, Washburn W, et al.
Toxicol Sci
. 2016 Dec;
155(2):379-388.
PMID: 28025230
The objective of this work was to investigate the mechanisms of hepatobiliary toxicity caused by thienopyrimidone MCHR1 antagonists using BMS-773174 as a tool molecule. Co-administration of the pan CYP inhibitor...
10.
Jain A, van der Meer A, Papa A, Barrile R, Lai A, Schlechter B, et al.
Biomed Microdevices
. 2016 Jul;
18(4):73.
PMID: 27464497
The vascular endothelium and shear stress are critical determinants of physiological hemostasis and platelet function in vivo, yet current diagnostic and monitoring devices do not fully incorporate endothelial function under...