Monica Bisbocci
Overview
Explore the profile of Monica Bisbocci including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
156
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0
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Recent Articles
1.
Ponzi S, Ferrigno F, Bisbocci M, Alli C, Ontoria J, Petrocchi A, et al.
Bioorg Med Chem Lett
. 2024 Jan;
100:129626.
PMID: 38266789
Tyrosine phosphatase SHP2 is a proto-oncogenic protein involved in cell growth and differentiation via diverse intracellular signaling pathways. With the scope of identifying new SHP2 allosteric inhibitors, we report here...
2.
Petrocchi A, Grillo A, Ferrante L, Randazzo P, Prandi A, De Matteo M, et al.
ACS Med Chem Lett
. 2023 May;
14(5):645-651.
PMID: 37197453
Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is the first reported nonreceptor oncogenic tyrosine phosphatase connecting multiple signal transduction cascades and exerting immunoinhibitory function through the PD-1 checkpoint receptor....
3.
Acchioni C, Acchioni M, Mancini F, Amendola A, Marsili G, Tirelli V, et al.
Virology
. 2023 Apr;
583:1-13.
PMID: 37060797
Type I interferon (IFN-I) evasion by Dengue virus (DENV) is key in DENV pathogenesis. The non-structural protein 5 (NS5) antagonizes IFN-I response through the degradation of the signal transducer and...
4.
Torrente E, Fodale V, Ciammaichella A, Ferrigno F, Ontoria J, Ponzi S, et al.
ACS Med Chem Lett
. 2023 Feb;
14(2):156-162.
PMID: 36793438
Protein tyrosine phosphatase SHP2 is an oncogenic protein that can regulate different cytokine receptor and receptor tyrosine kinase signaling pathways. We report here the identification of a novel series of...
5.
Paonessa G, Siciliano G, Graziani R, Lalli C, Cecchetti O, Alli C, et al.
Commun Biol
. 2022 Jun;
5(1):547.
PMID: 35668202
Blocking Plasmodium falciparum human-to-mosquito transmission is essential for malaria elimination, nonetheless drugs killing the pathogenic asexual stages are generally inactive on the parasite transmissible stages, the gametocytes. Due to technical...
6.
Fodale V, Pintauro R, Daldin M, Altobelli R, Spiezia M, Bisbocci M, et al.
Sci Rep
. 2020 Dec;
10(1):22137.
PMID: 33335120
Huntington's disease (HD) is a monogenetic neurodegenerative disorder that is caused by the expansion of a polyglutamine region within the huntingtin (HTT) protein, but there is still an incomplete understanding...
7.
Breveglieri G, Salvatori F, Finotti A, Cosenza L, Zuccato C, Bianchi N, et al.
Anal Bioanal Chem
. 2019 Jul;
411(29):7669-7680.
PMID: 31273412
There is a general agreement that pharmacologically mediated stimulation of human γ-globin gene expression and increase of production of fetal hemoglobin (HbF) is a potential therapeutic approach in the experimental...
8.
Lania G, Bresciani A, Bisbocci M, Francone A, Colonna V, Altamura S, et al.
Hum Mol Genet
. 2017 Oct;
26(22):4540.
PMID: 29036321
No abstract available.
9.
Lania G, Bresciani A, Bisbocci M, Francone A, Colonna V, Altamura S, et al.
Hum Mol Genet
. 2017 Feb;
25(20):4369-4375.
PMID: 28173146
Pathological conditions caused by reduced dosage of a gene, such as gene haploinsufficiency, can potentially be reverted by enhancing the expression of the functional allele. In practice, low specificity of...
10.
Torrisi C, Bisbocci M, Ingenito R, Ontoria J, Rowley M, Schultz-Fademrecht C, et al.
Bioorg Med Chem Lett
. 2009 Dec;
20(2):448-52.
PMID: 20015648
A novel hexahydrobenzonaphthyridinone PARP-1 pharmacophore is reported, subsequent SAR exploration around this scaffold led to selective PARP-1 inhibitors with low nanomolar enzyme potency, displaying good cellular activity and promising rat...