Molly Gasperini
Overview
Explore the profile of Molly Gasperini including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
1102
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0
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Recent Articles
1.
Hunker A, Mich J, Taskin N, Torkelson A, Pham T, Bertagnolli D, et al.
bioRxiv
. 2025 Jan;
PMID: 39868122
-acting regulatory enhancer elements are valuable tools for gaining cell type-specific genetic access. Leveraging large chromatin accessibility atlases, putative enhancer sequences can be identified and deployed in adeno-associated virus (AAV)...
2.
Ben-Simon Y, Hooper M, Narayan S, Daigle T, Dwivedi D, Way S, et al.
bioRxiv
. 2024 Jun;
PMID: 38915722
The mammalian cortex is comprised of cells classified into types according to shared properties. Defining the contribution of each cell type to the processes guided by the cortex is essential...
3.
McFaline-Figueroa J, Srivatsan S, Hill A, Gasperini M, Jackson D, Saunders L, et al.
Cell Genom
. 2024 Jan;
4(2):100487.
PMID: 38278156
Chemical genetic screens are a powerful tool for exploring how cancer cells' response to drugs is shaped by their mutations, yet they lack a molecular view of the contribution of...
4.
McFaline-Figueroa J, Srivatsan S, Hill A, Gasperini M, Jackson D, Saunders L, et al.
bioRxiv
. 2023 Jul;
PMID: 37398090
Chemical genetic screens are a powerful tool for exploring how cancer cells' response to drugs is shaped by their mutations, yet they lack a molecular view of the contribution of...
5.
Bloom J, Sathe L, Munugala C, Jones E, Gasperini M, Lubock N, et al.
Nat Biomed Eng
. 2021 Jul;
5(7):657-665.
PMID: 34211145
Frequent and widespread testing of members of the population who are asymptomatic for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for the mitigation of the transmission of the...
6.
Bloom J, Sathe L, Munugala C, Jones E, Gasperini M, Lubock N, et al.
medRxiv
. 2020 Sep;
PMID: 32909008
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is due to the high rates of transmission by individuals who are asymptomatic at the time of transmission. Frequent,...
7.
Gasperini M, Tome J, Shendure J
Nat Rev Genet
. 2020 Jan;
21(5):292-310.
PMID: 31988385
The human gene catalogue is essentially complete, but we lack an equivalently vetted inventory of bona fide human enhancers. Hundreds of thousands of candidate enhancers have been nominated via biochemical...
8.
Gasperini M, Hill A, McFaline-Figueroa J, Martin B, Kim S, Zhang M, et al.
Cell
. 2019 Mar;
176(6):1516.
PMID: 30849375
No abstract available.
9.
Gasperini M, Hill A, McFaline-Figueroa J, Martin B, Kim S, Zhang M, et al.
Cell
. 2019 Jan;
176(1-2):377-390.e19.
PMID: 30612741
Over one million candidate regulatory elements have been identified across the human genome, but nearly all are unvalidated and their target genes uncertain. Approaches based on human genetics are limited...
10.
Findlay G, Daza R, Martin B, Zhang M, Leith A, Gasperini M, et al.
Nature
. 2018 Sep;
562(7726):217-222.
PMID: 30209399
Variants of uncertain significance fundamentally limit the clinical utility of genetic information. The challenge they pose is epitomized by BRCA1, a tumour suppressor gene in which germline loss-of-function variants predispose...