Mohan Manikkam
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Explore the profile of Mohan Manikkam including associated specialties, affiliations and a list of published articles.
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24
Citations
2391
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Recent Articles
1.
Khaliq M, Manikkam M, Martinez E, Fallahi-Sichani M
Nat Commun
. 2021 Mar;
12(1):1536.
PMID: 33750776
Hyperactivation of the MAPK signaling pathway motivates the clinical use of MAPK inhibitors for BRAF-mutant melanomas. Heterogeneity in differentiation state due to epigenetic plasticity, however, results in cell-to-cell variability in...
2.
Arnold J, Gu F, Ambati C, Rasaily U, Ramirez-Pena E, Joseph R, et al.
Oncogene
. 2020 Mar;
39(15):3226-3228.
PMID: 32214199
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
3.
Comandante-Lou N, Khaliq M, Venkat D, Manikkam M, Fallahi-Sichani M
PLoS Comput Biol
. 2020 Feb;
16(2):e1007688.
PMID: 32084135
Cell-to-cell variability generates subpopulations of drug-tolerant cells that diminish the efficacy of cancer drugs. Efficacious combination therapies are thus needed to block drug-tolerant cells via minimizing the impact of heterogeneity....
4.
Arnold J, Gu F, Ambati C, Rasaily U, Ramirez-Pena E, Joseph R, et al.
Oncogene
. 2019 Jul;
39(15):3089-3101.
PMID: 31308490
An improved understanding of the biochemical alterations that accompany tumor progression and metastasis is necessary to inform the next generation of diagnostic tools and targeted therapies. Metabolic reprogramming is known...
5.
Kaushik A, Shojaie A, Panzitt K, Sonavane R, Venghatakrishnan H, Manikkam M, et al.
Nat Commun
. 2016 May;
7:11612.
PMID: 27194471
The precise molecular alterations driving castration-resistant prostate cancer (CRPC) are not clearly understood. Using a novel network-based integrative approach, here, we show distinct alterations in the hexosamine biosynthetic pathway (HBP)...
6.
Manikkam M, Haque M, Guerrero-Bosagna C, Nilsson E, Skinner M
PLoS One
. 2014 Jul;
9(7):e102091.
PMID: 25057798
Environmental compounds including fungicides, plastics, pesticides, dioxin and hydrocarbons can promote the epigenetic transgenerational inheritance of adult-onset disease in future generation progeny following ancestral exposure during the critical period of...
7.
Skinner M, Manikkam M, Tracey R, Guerrero-Bosagna C, Haque M, Nilsson E
BMC Med
. 2013 Nov;
11:228.
PMID: 24228800
Background: Ancestral environmental exposures to a variety of environmental factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The present work examined the...
8.
Tracey R, Manikkam M, Guerrero-Bosagna C, Skinner M
Reprod Toxicol
. 2013 Mar;
36:104-16.
PMID: 23453003
Environmental compounds have been shown to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a hydrocarbon mixture involving jet fuel (JP-8) promotes epigenetic transgenerational...
9.
Manikkam M, Tracey R, Guerrero-Bosagna C, Skinner M
PLoS One
. 2013 Jan;
8(1):e55387.
PMID: 23359474
Environmental compounds are known to promote epigenetic transgenerational inheritance of adult onset disease in subsequent generations (F1-F3) following ancestral exposure during fetal gonadal sex determination. The current study was designed...
10.
Manikkam M, Tracey R, Guerrero-Bosagna C, Skinner M
PLoS One
. 2012 Oct;
7(9):e46249.
PMID: 23049995
Environmental compounds can promote epigenetic transgenerational inheritance of adult-onset disease in subsequent generations following ancestral exposure during fetal gonadal sex determination. The current study examined the ability of dioxin (2,3,7,8-tetrachlorodibenzo[p]dioxin,...