Arun Sreekumar
Overview
Explore the profile of Arun Sreekumar including associated specialties, affiliations and a list of published articles.
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Articles
112
Citations
5368
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Recent Articles
1.
Kami Reddy K, Piyarathna D, Park J, Putluri V, Amara C, Kamal A, et al.
JCI Insight
. 2024 Sep;
9(17).
PMID: 39253977
Bladder cancer (BLCA) mortality is higher in African American (AA) patients compared with European American (EA) patients, but the molecular mechanism underlying race-specific differences are unknown. To address this gap,...
2.
Meena J, Wang J, Neill N, Keough D, Putluri N, Katsonis P, et al.
Cancer Discov
. 2024 Aug;
14(9):1699-1716.
PMID: 39193992
Upregulation of MYC is a hallmark of cancer, wherein MYC drives oncogenic gene expression and elevates total RNA synthesis across cancer cell transcriptomes. Although this transcriptional anabolism fuels cancer growth...
3.
Jin F, Thaiparambil J, Donepudi S, Vantaku V, Piyarathna D, Maity S, et al.
Cancer Prev Res (Phila)
. 2024 Jun;
17(6):281.
PMID: 38831722
No abstract available.
4.
Zhu Q, Balasubramanian A, Asirvatham J, Piyarathna D, Kaur J, Mohamed N, et al.
bioRxiv
. 2024 Apr;
PMID: 38562769
Racial disparities in triple-negative breast cancer (TNBC) outcomes have been reported. However, the biological mechanisms underlying these disparities remain unclear. We integrated imaging mass cytometry and spatial transcriptomics, to characterize...
5.
Amara C, Kami Reddy K, Yuntao Y, Chan Y, Piyarathna D, Dobrolecki L, et al.
Nat Commun
. 2024 Feb;
15(1):1373.
PMID: 38355560
SMARCB1 loss has long been observed in many solid tumors. However, there is a need to elucidate targetable pathways driving growth and metastasis in SMARCB1-deficient tumors. Here, we demonstrate that...
6.
Charles C, Lloyd S, Piyarathna D, Gohlke J, Rasaily U, Putluri V, et al.
Am J Clin Exp Urol
. 2023 Dec;
11(6):594-612.
PMID: 38148936
Prostate cancer (PCa) is the second most common cancer and constitutes about 14.7% of total cancer cases. PCa is highly prevalent and more aggressive in African-American (AA) men than in...
7.
Nguyen T, Sridaran D, Chouhan S, Weimholt C, Wilson A, Luo J, et al.
Nat Commun
. 2023 Sep;
14(1):6022.
PMID: 37758702
No abstract available.
8.
Kim B, Zheng Z, Lei J, Holt M, Chen A, Peng J, et al.
Cancer Res Commun
. 2023 Jul;
3(7):1366-1377.
PMID: 37501682
Significance: A major challenge for targeting the consequence of tumor suppressor disruption is the accurate assessment of protein functional inactivation. NF1 can repress both RAS and ER signaling, and a...
9.
Krieger K, Mann E, Lee K, Bolterstein E, Jebakumar D, Ittmann M, et al.
DNA Repair (Amst)
. 2023 Jun;
128:103529.
PMID: 37390674
DNA adducts and strand breaks are induced by various exogenous and endogenous agents. Accumulation of DNA damage is implicated in many disease processes, including cancer, aging, and neurodegeneration. The continuous...
10.
Nguyen T, Sridaran D, Chouhan S, Weimholt C, Wilson A, Luo J, et al.
Nat Commun
. 2023 Jun;
14(1):3357.
PMID: 37296155
The testicular androgen biosynthesis is well understood, however, how cancer cells gauge dwindling androgen to dexterously initiate its de novo synthesis remained elusive. We uncover dual-phosphorylated form of sterol regulatory...