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Mohammed Repon Khan

Explore the profile of Mohammed Repon Khan including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 323
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Recent Articles
1.
Ashraf D, Khan M, Dawson T, Dawson V
Int J Mol Sci . 2024 Feb; 25(4). PMID: 38397070
In recent years, research into Parkinson's disease and similar neurodegenerative disorders has increasingly suggested that these conditions are synonymous with failures in proteostasis. However, the spotlight of this research has...
2.
Khan M, Yin X, Kang S, Mitra J, Wang H, Ryu T, et al.
Sci Transl Med . 2023 Nov; 15(724):eadd0499. PMID: 38019930
Pathologic α-synuclein plays an important role in the pathogenesis of α-synucleinopathies such as Parkinson's disease (PD). Disruption of proteostasis is thought to be central to pathologic α-synuclein toxicity; however, the...
3.
Umanah G, Abalde-Atristain L, Khan M, Mitra J, Dar M, Chang M, et al.
Nat Commun . 2022 Aug; 13(1):4836. PMID: 35977929
The mechanistic target of rapamycin (mTOR) signals through the mTOR complex 1 (mTORC1) and the mTOR complex 2 to maintain cellular and organismal homeostasis. Failure to finely tune mTOR activity...
4.
Kim J, Yin X, Jhaldiyal A, Khan M, Martin I, Xie Z, et al.
Cell Stem Cell . 2020 Aug; 27(4):633-645.e7. PMID: 32846140
The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause of familial Parkinson's disease (PD). This mutation results in dopaminergic neurodegeneration via dysregulated protein translation, although how...
5.
Agarwal A, Park S, Ha S, Kwon J, Khan M, Kang B, et al.
PLoS One . 2020 Apr; 15(4):e0231978. PMID: 32315348
Ischemic strokes result in the death of brain tissue and a wave of downstream effects, often leading to lifelong disabilities or death. However, the underlying mechanisms of ischemic damage and...
6.
Pirooznia S, Yuan C, Khan M, Karuppagounder S, Wang L, Xiong Y, et al.
Mol Neurodegener . 2020 Mar; 15(1):17. PMID: 32138754
Background: Mutations in PINK1 and parkin cause autosomal recessive Parkinson's disease (PD). Evidence placing PINK1 and parkin in common pathways regulating multiple aspects of mitochondrial quality control is burgeoning. However,...
7.
Li L, Sanchez C, Slaughter B, Zhao Y, Khan M, Unruh J, et al.
Curr Biol . 2016 Nov; 26(23):3143-3156. PMID: 27818176
How a transient experience creates an enduring yet dynamic memory remains an unresolved issue in studies of memory. Experience-dependent aggregation of the RNA-binding protein CPEB/Orb2 is one of the candidate...
8.
Khan M, Li L, Perez-Sanchez C, Saraf A, Florens L, Slaughter B, et al.
Cell . 2015 Dec; 163(6):1468-83. PMID: 26638074
Memories are thought to be formed in response to transient experiences, in part through changes in local protein synthesis at synapses. In Drosophila, the amyloidogenic (prion-like) state of the RNA...
9.
Majumdar A, Cesario W, White-Grindley E, Jiang H, Ren F, Khan M, et al.
Cell . 2012 Jan; 148(3):515-29. PMID: 22284910
A long-standing question in the study of long-term memory is how a memory trace persists for years when the proteins that initiated the process turn over and disappear within days....