Mohammed Enamul Hoque
Overview
Explore the profile of Mohammed Enamul Hoque including associated specialties, affiliations and a list of published articles.
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13
Citations
77
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Recent Articles
1.
Kabir M, Kodikara S, Hoque M, Shiekh S, Alfehaid J, Basu S, et al.
NAR Mol Med
. 2025 Feb;
2(1):ugaf001.
PMID: 39906285
We demonstrate that both Clustered regularly interspaced short palindromic repeats (CRISPR) interference and CRISPR activation can be achieved at RNA and protein levels by targeting the vicinity of a putative...
2.
Kabir M, Kodikara S, Hoque M, Shiekh S, Alfehaid J, Basu S, et al.
bioRxiv
. 2024 Nov;
PMID: 39605509
We demonstrate that both CRISPR interference and CRISPR activation can be achieved at RNA and protein levels by targeting the vicinity of a putative G-quadruplex forming sequence (PQS) in the...
3.
Hoque M, Kabir M, Shiekh S, Balci H, Basu S
bioRxiv
. 2024 Apr;
PMID: 38559215
Putative G-quadruplex forming sequences (PQS) have been identified in promoter sequences of prominent genes that are implicated among others in cancer and neurological disorders. We explored mechanistic aspects of CRISPR-dCas9-mediated...
4.
Shiekh S, Jack A, Saurabh A, Mustafa G, Kodikara S, Gyawali P, et al.
Nucleic Acids Res
. 2022 Dec;
50(22):12885-12895.
PMID: 36511858
Telomeres terminate with a 50-300 bases long single-stranded G-rich overhang, which can be misrecognized as a DNA damage repair site. Shelterin plays critical roles in maintaining and protecting telomere ends...
5.
Shiekh S, Mustafa G, Kodikara S, Hoque M, Yokie E, Portman J, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(30):e2202317119.
PMID: 35858438
We present single-molecule experimental and computational modeling studies investigating the accessibility of human telomeric overhangs of physiologically relevant lengths. We studied 25 different overhangs that contain 4-28 repeats of GGGTTA...
6.
Balaratnam S, Hoque M, West N, Basu S
ACS Chem Biol
. 2022 Jun;
17(7):1723-1732.
PMID: 35687865
Piwi-interacting RNAs (piRNAs) are a group of small noncoding RNA molecules that regulate the activity of transposons and control gene expression. The cellular concentration of RNAs is generally maintained by...
7.
Hoque M, Mahendran T, Basu S
Biomolecules
. 2022 Feb;
12(2).
PMID: 35204814
G-quadruplexes (GQs) are secondary nucleic acid structures that play regulatory roles in various cellular processes. G-quadruplex-forming sequences present within the 5' UTR of mRNAs can function not only as repressors...
8.
Hoque M, Mustafa G, Basu S, Balci H
ACS Synth Biol
. 2021 May;
10(5):972-978.
PMID: 33970608
Using the nuclease-dead Cas9 (dCas9), we targeted a G-rich sequence, which contains multiple potentially G-quadruplex (GQ) forming sites, within the human tyrosine hydroxylase (TH) promoter. We demonstrate that transcription can...
9.
Pandey S, Kankanamalage D, Zhou X, Hu C, Hoque M, Isaacs L, et al.
J Am Chem Soc
. 2020 Aug;
142(34):14750.
PMID: 32787243
No abstract available.
10.
Mandal S, Hoque M, Mao H
Methods Mol Biol
. 2019 Aug;
2035:275-298.
PMID: 31444756
The genome-wide occurrence of G-quadruplexes and their demonstrated biological activities call for detailed understanding on the stability and transition kinetics of the structures. Although the core structural element in a...