Mohammad R Ahmadian
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Explore the profile of Mohammad R Ahmadian including associated specialties, affiliations and a list of published articles.
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Articles
49
Citations
1021
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Recent Articles
11.
Mosaddeghzadeh N, Pudewell S, Bazgir F, Kazemein Jasemi N, Krumbach O, Gremer L, et al.
Int J Mol Sci
. 2022 Aug;
23(16).
PMID: 36012107
The IQ motif-containing GTPase-activating protein (IQGAP) family composes of three highly-related and evolutionarily conserved paralogs (IQGAP1, IQGAP2 and IQGAP3), which fine tune as scaffolding proteins numerous fundamental cellular processes. IQGAP1...
12.
Nauth T, Bazgir F, Voss H, Brandenstein L, Mosaddeghzadeh N, Rickassel V, et al.
Hum Mol Genet
. 2022 Aug;
32(2):304-318.
PMID: 35981076
Heterozygous germline missense variants in the HRAS gene underlie Costello syndrome (CS). The molecular basis for cutaneous manifestations in CS is largely unknown. We used an immortalized human cell line,...
13.
Meng J, Chen C, Ahmadian M, Zan H, Kai-Jun Luo , Jiang J
Front Immunol
. 2022 Aug;
13:882706.
PMID: 35911693
Hemichannels (HCs)/gap junctions (GJs) and immunoglobulin (Ig)-like domain-containing proteins (IGLDCPs) are involved in the innate-adaptive immune response independently. Despite of available evidence demonstrating the importance of HCs/GJs and IGLDCPs in...
14.
Kazemein Jasemi N, Ahmadian M
Small GTPases
. 2022 Jun;
13(1):282-286.
PMID: 35703160
RAS activation is a multiple-step process in which linkage of the extracellular stimuli to the RAS activator SOS1 is the main step in RAS activation. GRB2 adaptor protein is the...
15.
Mosaddeghzadeh N, Nouri K, Krumbach O, Amin E, Dvorsky R, Ahmadian M
Int J Mol Sci
. 2021 Nov;
22(22).
PMID: 34830479
IQ motif-containing GTPase-activating proteins (IQGAPs) modulate a wide range of cellular processes by acting as scaffolds and driving protein components into distinct signaling networks. Their functional states have been proposed...
16.
Heise D, Derrac Soria A, Hansen S, Dambietz C, Akbarzadeh M, Berg A, et al.
Sci Signal
. 2021 Aug;
14(696).
PMID: 34404751
The cytokine interleukin-6 (IL-6) signals through three mechanisms called classic signaling, trans-signaling, and trans-presentation. IL-6 trans-signaling is distinctly mediated through a soluble form of its transmembrane receptor IL-6R (sIL-6R) and...
17.
Kazemein Jasemi N, Herrmann C, Magdalena Estirado E, Gremer L, Willbold D, Brunsveld L, et al.
Biochem J
. 2021 Jul;
478(14):2793-2809.
PMID: 34232285
Growth factor receptor-bound protein 2 (GRB2) is a trivalent adaptor protein and a key element in signal transduction. It interacts via its flanking nSH3 and cSH3 domains with the proline-rich...
18.
Pudewell S, Wittich C, Kazemein Jasemi N, Bazgir F, Ahmadian M
Commun Biol
. 2021 Jun;
4(1):696.
PMID: 34103645
Health and disease are directly related to the RTK-RAS-MAPK signalling cascade. After more than three decades of intensive research, understanding its spatiotemporal features is afflicted with major conceptual shortcomings. Here...
19.
Rezaei Adariani S, Kazemein Jasemi N, Bazgir F, Wittich C, Amin E, Seidel C, et al.
J Biol Chem
. 2021 Apr;
296:100626.
PMID: 33930461
RAS effectors specifically interact with GTP-bound RAS proteins to link extracellular signals to downstream signaling pathways. These interactions rely on two types of domains, called RAS-binding (RB) and RAS association...
20.
Straub T, Nave J, Bouvain P, Akbarzadeh M, Dasa S, Kistner J, et al.
Sci Rep
. 2020 Dec;
10(1):21669.
PMID: 33303866
After myocardial infarction (MI), epicardial cells reactivate their embryonic program, proliferate and migrate into the damaged tissue to differentiate into fibroblasts, endothelial cells and, if adequately stimulated, to cardiomyocytes. Targeting...