Mohammad Abu-Odeh
Overview
Explore the profile of Mohammad Abu-Odeh including associated specialties, affiliations and a list of published articles.
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12
Citations
338
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Recent Articles
1.
Amar-Schwartz A, Ben Hur V, Jbara A, Cohen Y, Barnabas G, Arbib E, et al.
Elife
. 2022 Oct;
11.
PMID: 36189922
The mTORC1 substrate, S6 Kinase 1 (S6K1), is involved in the regulation of cell growth, ribosome biogenesis, glucose homeostasis, and adipogenesis. Accumulating evidence has suggested a role for mTORC1 signaling...
2.
Valentine J, Ahmadian M, Keinan O, Abu-Odeh M, Zhao P, Zhou X, et al.
J Clin Invest
. 2021 Nov;
132(2).
PMID: 34847077
The dysregulation of energy homeostasis in obesity involves multihormone resistance. Although leptin and insulin resistance have been well characterized, catecholamine resistance remains largely unexplored. Murine β3-adrenergic receptor expression in adipocytes...
3.
Keinan O, Valentine J, Xiao H, Mahata S, Reilly S, Abu-Odeh M, et al.
Nature
. 2021 Oct;
599(7884):296-301.
PMID: 34707293
Adipocytes increase energy expenditure in response to prolonged sympathetic activation via persistent expression of uncoupling protein 1 (UCP1). Here we report that the regulation of glycogen metabolism by catecholamines is...
4.
Abu-Odeh M, Zhang Y, Reilly S, Ebadat N, Keinan O, Valentine J, et al.
Cell Rep
. 2021 Jun;
35(13):109331.
PMID: 34192547
The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires autocrine FGF21 signaling. Adipose-specific deletion...
5.
Reilly S, Abu-Odeh M, Ameka M, DeLuca J, Naber M, Dadpey B, et al.
J Clin Invest
. 2021 Apr;
131(10).
PMID: 33822771
The protein kinases IKKε and TBK1 are activated in liver and fat in mouse models of obesity. We have previously demonstrated that treatment with the IKKε/TBK1 inhibitor amlexanox produces weight...
6.
Huh J, Reilly S, Abu-Odeh M, Murphy A, Mahata S, Zhang J, et al.
Cell Metab
. 2020 Nov;
32(6):1012-1027.e7.
PMID: 33152322
Hepatic TANK (TRAF family member associated NFκB activator)-binding kinase 1 (TBK1) activity is increased during obesity, and administration of a TBK1 inhibitor reduces fatty liver. Surprisingly, liver-specific TBK1 knockout in...
7.
Del Mare S, Husanie H, Iancu O, Abu-Odeh M, Evangelou K, Lovat F, et al.
Cancer Res
. 2016 Aug;
76(20):6107-6117.
PMID: 27550453
Osteosarcoma is a highly metastatic form of bone cancer in adolescents and young adults that is resistant to existing treatments. Development of an effective therapy has been hindered by very...
8.
Hazan I, Abu-Odeh M, Hofmann T, Aqeilan R
Mol Cell Oncol
. 2016 Jun;
2(4):e1008288.
PMID: 27308504
Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be "hot spots" for genomic instability. Recent evidence, however, implies that in the wake of...
9.
Abu-Odeh M, Hereema N, Aqeilan R
Oncotarget
. 2015 Dec;
7(4):4344-55.
PMID: 26675548
For many decades genomic instability is considered one of the hallmarks of cancer. Role of the tumor suppressor WWOX (WW domain-containing oxidoreductase) in DNA damage response upon double strand breaks...
10.
Abu-Odeh M, Salah Z, Herbel C, Hofmann T, Aqeilan R
Proc Natl Acad Sci U S A
. 2014 Oct;
111(44):E4716-25.
PMID: 25331887
Genomic instability is a hallmark of cancer. The WW domain-containing oxidoreductase (WWOX) is a tumor suppressor spanning the common chromosomal fragile site FRA16D. Here, we report a direct role of...