Moh Panesar
Overview
Explore the profile of Moh Panesar including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
134
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0
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Recent Articles
1.
Morozzi G, Rothen J, Toussaint G, De Lange K, Westritschnig K, Doelemeyer A, et al.
iScience
. 2021 Dec;
24(12):103434.
PMID: 34877494
Inflammatory responses are crucial for regeneration following peripheral nerve injury (PNI). PNI triggers inflammatory responses at the site of injury. The DNA-sensing receptor cyclic GMP-AMP synthase (cGAS) and its downstream...
2.
Giorgetti E, Panesar M, Zhang Y, Joller S, Ronco M, Obrecht M, et al.
Cell Rep
. 2019 Nov;
29(6):1539-1554.e7.
PMID: 31693894
Age-related loss of skeletal muscle innervation by motor neurons leads to impaired neuromuscular function and is a well-established clinical phenomenon. However, the underlying pathogenesis remains unclear. Studying mice, we find...
3.
Giorgetti E, Obrecht M, Ronco M, Panesar M, Lambert C, Accart N, et al.
Sci Rep
. 2019 Sep;
9(1):13508.
PMID: 31534149
Assessment of myelin integrity in peripheral nerve injuries and pathologies has largely been limited to post-mortem analysis owing to the difficulty in obtaining biopsies without affecting nerve function. This is...
4.
Rooney L, Vidal A, DSouza A, Devereux N, Masick B, Boissel V, et al.
J Med Chem
. 2014 Jun;
57(12):5129-40.
PMID: 24884675
A high throughput screening campaign identified 5-(2-chlorophenyl)indazole compound 4 as an antagonist of the transient receptor potential A1 (TRPA1) ion channel with IC50 = 1.23 μM. Hit to lead medicinal...
5.
Nash M, McIntyre P, Groarke A, Lilley E, Culshaw A, Hallett A, et al.
J Pharmacol Exp Ther
. 2012 May;
342(2):389-98.
PMID: 22566669
The therapeutic potential of transient receptor potential vanilloid type 1 (TRPV1) antagonists for chronic pain has been recognized for more than a decade. However, preclinical and clinical data revealed that...
6.
Watson R, Lilley E, Panesar M, Bhalay G, Langridge S, Tian S, et al.
Neurogastroenterol Motil
. 2011 Nov;
24(1):65-75, e12.
PMID: 22050240
Background: Prokineticin 2 (PROK2) is an inflammatory cytokine-like molecule expressed predominantly by macrophages and neutrophils infiltrating sites of tissue damage. Given the established role of prokineticin signaling on gastrointestinal function,...
7.
Culshaw A, Bevan S, Christiansen M, Copp P, Davis A, Davis C, et al.
J Med Chem
. 2006 Jan;
49(2):471-4.
PMID: 16420034
Vanilloid receptor 1 (VR1, TRPV1) is a cation-selective ion channel that is expressed on primary afferent neurons and is upregulated following inflammation and nerve damage. Blockers of this channel may...
8.
Fox A, Kaur S, Li B, Panesar M, Saha U, Davis C, et al.
Br J Pharmacol
. 2005 Feb;
144(7):889-99.
PMID: 15685199
We describe the properties of a novel nonpeptide kinin B1 receptor antagonist, NVP-SAA164, and demonstrate its in vivo activity in models of inflammatory pain in transgenic mice expressing the human...
9.
Urban L, Campbell E, Panesar M, Patel S, Chaudhry N, Kane S, et al.
Pain
. 2000 Dec;
89(1):65-74.
PMID: 11113294
Capsaicin and analogues are valuable analgesic agents when administered to mammals, including humans. However, their pungency and the effects on the cardiovascular and respiratory systems through their general activation of...