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Mitsuru Hashimoto

Explore the profile of Mitsuru Hashimoto including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 12
Citations 75
Followers 0
Related Specialties
Pharmacology
Biochemistry
Cell Biology
Top 10 Co-Authors
Yasuo Shinohara
Hiroshi Terada
Teruko Imai
Eiji Majima
Kazuto Ohkura
Yoshitaka Kihira
Naoshi Yamazaki
Takenori Yamamoto
John E Wilson
Hisae Sakamoto
Published In
Drug Metab Dispos
Mitochondrion
Arch Biochem Biophys
Pharm Res
Protein Expr Purif
Affiliations
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Recent Articles
1.
Overexpression of carboxylesterase contributes to the attenuation of cyanotoxin microcystin-LR toxicity
Takumi S, Shimono T, Ikema S, Hotta Y, Chigwechokha P, Shiozaki K, et al.
Comp Biochem Physiol C Toxicol Pharmacol . 2017 Feb; 194:22-27. PMID: 28163251
Microcystin-LR is a hepatotoxin produced by several cyanobacteria. Its toxicity is mainly due to a inhibition of protein phosphatase, PP1 and PP2A. Previously, we used a cell line stably expressing...
2.
Identification of amino acid residues of mammalian mitochondrial phosphate carrier important for its functional expression in yeast cells, as achieved by PCR-mediated random mutation and gap-repair cloning
Yamagoshi R, Yamamoto T, Hashimoto M, Sugahara R, Shiotsuki T, Miyoshi H, et al.
Mitochondrion . 2016 Nov; 32:1-9. PMID: 27836624
The mitochondrial phosphate carrier (PiC) of mammals, but not the yeast one, is synthesized with a presequence. The deletion of this presequence of the mammalian PiC was reported to facilitate...
3.
Involvement of Carboxylesterase in Hydrolysis of Propranolol Prodrug during Permeation across Rat Skin
Imai T, Takase Y, Iwase H, Hashimoto M
Pharmaceutics . 2013 Dec; 5(3):371-84. PMID: 24300511
The use of a prodrug, a conjugate of an active drug with a lipophilic substituent, is a good way of increasing the cutaneous absorption of a drug. However, the activity...
4.
Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine
Ohura K, Tasaka K, Hashimoto M, Imai T
Drug Metab Dispos . 2013 Nov; 42(2):264-73. PMID: 24271336
The age-associated alteration in expression levels of carboxylesterases (CESs) can affect both intestinal and hepatic first-pass metabolism after oral administration of xenobiotic esters such as prodrugs. In this study, the...
5.
Comparison of two expression systems using COS7 cells and yeast cells for expression of heart/muscle-type carnitine palmitoyltransferase 1
Hada T, Kato Y, Obana E, Yamamoto A, Yamazaki N, Hashimoto M, et al.
Protein Expr Purif . 2012 Jan; 82(1):192-6. PMID: 22266133
Carnitine palmitoyltransferase 1 (CPT1), catalyzing the transfer of the acyl group from acyl-CoA to carnitine to form acylcarnitine, is located at the outer mitochondrial membrane. Because it is easily inactivated...
6.
[Structural and functional properties of the C-terminal region of mitochondrial ADP/ATP carrier]
Shinohara Y, Hashimoto M, Kihira Y, Ohkura K, Majima E, Terada H
Yakugaku Zasshi . 2010 Feb; 130(2):199-204. PMID: 20118643
Mitochondrial ADP/ATP carrier (AAC) is a protein catalyzing the transport of adenine nucleotides across inner mitochondrial membrane. In this review article, we first briefly introduce structural and functional properties of...
7.
Functionally important conserved length of C-terminal regions of yeast and bovine ADP/ATP carriers, identified by deletion mutants studies, and water accessibility of the amino acids at the C-terminal region of the yeast carrier
Iwahashi A, Ishii A, Yamazaki N, Hashimoto M, Ohkura K, Kataoka M, et al.
Mitochondrion . 2008 Mar; 8(2):196-204. PMID: 18313366
Comparison of the amino acid sequence of yeast type 2 ADP/ATP carrier (yAAC2) with that of bovine type 1 AAC (bAAC1) revealed that the N- and C-terminus of yAAC2 are...
8.
Intestinal first-pass metabolism via carboxylesterase in rat jejunum and ileum
Masaki K, Hashimoto M, Imai T
Drug Metab Dispos . 2007 Mar; 35(7):1089-95. PMID: 17392394
To determine the activity of a major intestinal esterase in the first-pass hydrolysis of O-isovaleryl-propranolol (isovaleryl-PL), a model ester compound, rat intestinal jejunum and blood vessels were perfused simultaneously after...
9.
An oral adsorbent, AST-120 protects against the progression of oxidative stress by reducing the accumulation of indoxyl sulfate in the systemic circulation in renal failure
Shimoishi K, Anraku M, Kitamura K, Tasaki Y, Taguchi K, Hashimoto M, et al.
Pharm Res . 2007 Mar; 24(7):1283-9. PMID: 17387602
Purpose: The effect of AST-120, an oral adsorbent, on oxidative stress in the systemic circulation in chronic renal failure (CRF) was examined and the potential role of indoxyl sulfate (IS),...
10.
Roles of adjoining Asp and Cys residues of first matrix-facing loop in transport activity of yeast and bovine mitochondrial ADP/ATP carriers
Kihira Y, Hashimoto M, Shinohara Y, Majima E, Terada H
J Biochem . 2006 Mar; 139(3):575-82. PMID: 16567423
The mitochondrial ADP/ATP carrier (AAC) transports substrate by interconversion of its conformation between m- and c-states. The 1st loop facing the matrix (LM1) is extruded into the matrix in the...