Mitsuhiro Hirode
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Explore the profile of Mitsuhiro Hirode including associated specialties, affiliations and a list of published articles.
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8
Citations
119
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Recent Articles
1.
Fukumoto H, Takahashi H, Tarui N, Matsui J, Tomita T, Hirode M, et al.
J Neurosci
. 2010 Aug;
30(33):11157-66.
PMID: 20720123
We discovered a nonpeptidic compound, TAK-070, that inhibited BACE1, a rate-limiting protease for the generation of Abeta peptides that are considered causative for Alzheimer's disease (AD), in a noncompetitive manner....
2.
Hirode M, Omura K, Kiyosawa N, Uehara T, Shimuzu T, Ono A, et al.
J Toxicol Sci
. 2009 Jun;
34(3):281-93.
PMID: 19483382
A large-scale transcriptome database of rat liver (TG-GATEs) has been established by the Toxicogenomics Project in Japan. In the present study, we focused on 8 hepatotoxic compounds within TG-GATEs, i.e.,...
3.
Uehara T, Hirode M, Ono A, Kiyosawa N, Omura K, Shimizu T, et al.
Toxicology
. 2008 Jul;
250(1):15-26.
PMID: 18619722
For assessing carcinogenicity in animals, it is difficult and costly, an alternative strategy has been desired. We explored the possibility of applying a toxicogenomics approach by using comprehensive gene expression...
4.
Hirode M, Ono A, Miyagishima T, Nagao T, Ohno Y, Urushidani T
Toxicol Appl Pharmacol
. 2008 Mar;
229(3):290-9.
PMID: 18355885
We have constructed a large-scale transcriptome database of rat liver treated with various drugs. In an effort to identify a biomarker for diagnosis of hepatic phospholipidosis, we extracted 78 probe...
5.
Uehara T, Kiyosawa N, Hirode M, Omura K, Shimizu T, Ono A, et al.
J Toxicol Sci
. 2008 Feb;
33(1):37-50.
PMID: 18303183
The present study was conducted as a model case of the toxicogenomics approach for analyzing toxicological mechanisms and toxicity assessments in the early stage of drug development by comparing with...
6.
Kiyosawa N, Uehara T, Gao W, Omura K, Hirode M, Shimizu T, et al.
J Toxicol Sci
. 2008 Jan;
32(5):469-86.
PMID: 18198479
To identify candidate biomarker gene sets to evaluate the potential risk of chemical-induced glutathione depletion in livers, we conducted microarray analysis on rat livers administered with phorone (40, 120 and...
7.
Omura K, Kiyosawa N, Uehara T, Hirode M, Shimizu T, Miyagishima T, et al.
J Toxicol Sci
. 2007 Oct;
32(4):387-99.
PMID: 17965553
We have constructed a large-scale transcriptome database of rat liver treated with various drugs. In an effort to identify a biomarker for interpretation of plasma triglyceride (TG) decrease, we extracted...
8.
Kiyosawa N, Shiwaku K, Hirode M, Omura K, Uehara T, Shimizu T, et al.
J Toxicol Sci
. 2007 Jan;
31(5):433-48.
PMID: 17202759
A large-scale toxicogenomcis database has now been constructed in the Toxicogenomics Project in Japan (TGP). To facilitate the analytical procedures for such large-scale microarray data, we developed a simple one-dimensional...