Mitsuaki Moriyama
Overview
Explore the profile of Mitsuaki Moriyama including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
539
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Recent Articles
1.
Minamihata T, Takano-Kawabe K, Moriyama M
Neurol Int
. 2024 Jul;
16(4):709-730.
PMID: 39051215
In Alzheimer's disease (AD) pathology, the accumulation of amyloid-beta (Aβ), a main component of senile plaques, activates glial cells and causes neuroinflammation. Excessive neuroinflammation results in neuronal dropouts and finally...
2.
Takano-Kawabe K, Izumo T, Minamihata T, Moriyama M
Curr Mol Pharmacol
. 2023 Nov;
PMID: 37916634
Background: Activation of microglia and astrocytes has been observed in Alzheimer's disease (AD). Transglutaminase 2 (TG2) is reported to be activated in AD and involved in cell proliferation, differentiation, and...
3.
Takano-Kawabe K, Matoba K, Nakamura Y, Moriyama M
Neurochem Res
. 2023 Sep;
49(1):199-211.
PMID: 37702891
Activation of glial cells, astrocytes and microglia, has been observed in neurodegenerative diseases including Alzheimer's disease (AD). Amyloid β (Aβ), which is aggregated and the aggregation is detected as characteristic...
4.
Minamihata T, Takano K, Nakamura Y, Seto R, Moriyama M
Neurochem Res
. 2021 Aug;
47(9):2602-2616.
PMID: 34383250
Mutations in alpha/beta-hydrolase domain containing (ABHD) 12 gene, which encodes lysophosphatidylserine (LysoPS) lipase, cause the neurodegenerative disease PHARC (Polyneuropathy, Hearing loss, Ataxia, Retinitis pigmentosa, Cataract). Since ABHD12 is expressed by...
5.
AGC2 (Citrin) Deficiency-From Recognition of the Disease till Construction of Therapeutic Procedures
Saheki T, Moriyama M, Funahashi A, Kuroda E
Biomolecules
. 2020 Jul;
10(8).
PMID: 32722104
Can you imagine a disease in which intake of an excess amount of sugars or carbohydrates causes hyperammonemia? It is hard to imagine the intake causing hyperammonemia. AGC2 or citrin...
6.
Minamihata T, Takano K, Moriyama M, Nakamura Y
Inflammation
. 2020 Jun;
43(5):1971-1987.
PMID: 32519268
Lysophosphatidylinositol (LysoPI), an endogenous ligand for G protein-coupled receptor (GPR) 55, has been known to show various functions in several tissues and cells; however, its roles in the central nervous...
7.
Moriyama M, Nishimura Y, Kurebayashi R, Minamihata T, Kawabe K, Takano K, et al.
Curr Mol Pharmacol
. 2020 Apr;
14(2):253-260.
PMID: 32310055
Aims: To show that acetate attenuates neuroinflammatory responses in activated microglia. Background: Dietary acetate supplementation alleviates neuroglial activation in a rat model of neuroinflammation induced by intraventricular administration of lipopolysaccharide...
8.
Saheki T, Moriyama M, Kuroda E, Funahashi A, Yasuda I, Setogawa Y, et al.
Sci Rep
. 2019 Mar;
9(1):4179.
PMID: 30862943
Previous studies using citrin/mitochondrial glycerol-3-phosphate (G3P) dehydrogenase (mGPD) double-knockout mice have demonstrated that increased dietary protein reduces the extent of carbohydrate-induced hyperammonemia observed in these mice. This study aimed to...
9.
Nishimura Y, Moriyama M, Kawabe K, Satoh H, Takano K, Azuma Y, et al.
Neurochem Res
. 2018 Jun;
43(9):1723-1735.
PMID: 29947014
In several neurodegenerative diseases such as Alzheimer's disease (AD), microglia are hyperactivated and release nitric oxide (NO) and proinflammatory cytokines, resulting its neuropathology. Mounting evidence indicates that dietary supplementation with...
10.
Moriyama M, Hashimoto A, Satoh H, Kawabe K, Ogawa M, Takano K, et al.
Int J Inflam
. 2018 Apr;
2018:8496973.
PMID: 29692883
Cumulative evidence indicates that estrogen receptor (ER) agonists attenuate neuroinflammation. Equol, a major isoflavone from soybean, exhibits estrogen-like biological activity, but their effect on inflammatory response has not been well...