Mithunah Krishnamoorthy
Overview
Explore the profile of Mithunah Krishnamoorthy including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
193
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Recent Articles
1.
Krishnamoorthy M, Seelige R, Brown C, Chau N, Nielsen Viller N, Johnson L, et al.
Front Immunol
. 2025 Mar;
16:1518787.
PMID: 40078999
Introduction: CD47 is highly expressed on cancer cells and triggers an anti-phagocytic "don't eat me" signal when bound by the inhibitory signal regulatory protein α (SIRPα) expressed on macrophages. While...
2.
Routy B, Lenehan J, Miller Jr W, Jamal R, Messaoudene M, Daisley B, et al.
Nat Med
. 2023 Nov;
30(2):604.
PMID: 37923839
No abstract available.
3.
Routy B, Lenehan J, Miller Jr W, Jamal R, Messaoudene M, Daisley B, et al.
Nat Med
. 2023 Jul;
29(8):2121-2132.
PMID: 37414899
Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has...
4.
El-Hajjar M, Gerhardt L, Hong M, Krishnamoorthy M, Figueredo R, Zheng X, et al.
Mol Ther
. 2022 Sep;
31(2):535-551.
PMID: 36068918
Immune checkpoint blockade can induce potent and durable responses in patients with highly immunogenic mismatch repair-deficient tumors; however, these drugs are ineffective against immune-cold neuroblastoma tumors. To establish a role...
5.
Krishnamoorthy M, Gerhardt L, Maleki Vareki S
Cells
. 2021 Jun;
10(5).
PMID: 34065010
The primary function of myeloid cells is to protect the host from infections. However, during cancer progression or states of chronic inflammation, these cells develop into myeloid-derived suppressor cells (MDSCs)...
6.
Krishnamoorthy M, Lenehan J, Maleki Vareki S
J Natl Cancer Inst
. 2021 Jan;
113(7):823-832.
PMID: 33432320
Neoadjuvant immunotherapy involves administering immune checkpoint inhibitors before surgical resection in high-risk resectable disease. This strategy was shown to have a high pathological response rate and prolonged relapse-free survival in...
7.
Krishnamoorthy M, Lenehan J, Burton J, Maleki Vareki S
Cancers (Basel)
. 2020 Nov;
12(11).
PMID: 33198059
Pancreatic cancer has a high mortality rate, and its incidence is increasing worldwide. The almost universal poor prognosis of pancreatic cancer is partly due to symptoms presenting only at late...
8.
Aguilar O, Sampaio I, Rahim M, Samaniego J, Tilahun M, Krishnamoorthy M, et al.
J Virol
. 2019 Oct;
94(1).
PMID: 31597762
Natural killer (NK) cells are a subset of innate lymphoid cells (ILC) capable of recognizing stressed and infected cells through multiple germ line-encoded receptor-ligand interactions. Missing-self recognition involves NK cell...
9.
Krishnamoorthy M, Wasim L, Buhari F, Zhao T, Mahtani T, Ho J, et al.
Sci Signal
. 2018 Jun;
11(533).
PMID: 29871912
Members of the transient receptor potential (TRP) family of ion channels are cellular sensors involved in numerous physiological and pathological processes. We identified the TRP subfamily M member 7 (TRPM7)...
10.
Krishnamoorthy M, Buhari F, Zhao T, Brauer P, Burrows K, Cao E, et al.
Sci Signal
. 2018 Jun;
11(533).
PMID: 29871911
The transient receptor potential (TRP) family is a large family of widely expressed ion channels that regulate the intracellular concentration of ions and metals and respond to various chemical and...