Mitchell F Denning
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Explore the profile of Mitchell F Denning including associated specialties, affiliations and a list of published articles.
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45
Citations
921
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Recent Articles
1.
Zhang L, Luo H, Ni H, Liu S, Xing H, Zhang J, et al.
Stem Cell Reports
. 2022 May;
17(6):1428-1441.
PMID: 35561683
Receptor-interacting protein kinase 3 (Ripk3) is one of the critical mediators of inflammatory cytokine-stimulated signaling. Here we show that Ripk3 signaling selectively regulates both the number and the function of...
2.
Liu S, Joshi K, Denning M, Zhang J
Cell Mol Life Sci
. 2021 Oct;
78(23):7199-7217.
PMID: 34654937
RIPK3 (receptor-interacting protein kinase 3) is a serine/threonine-protein kinase. As a key component of necrosomes, RIPK3 is an essential mediator of inflammatory factors (such as TNFα-tumor necrosis factor α) and...
3.
Wang H, Hou W, Perera A, Bettler C, Beach J, Ding X, et al.
Cell Rep
. 2021 Feb;
34(8):108765.
PMID: 33626345
Hepatocellular carcinoma (HCC) remains one of the deadliest malignancies worldwide. One major obstacle to treatment is a lack of effective molecular-targeted therapies. In this study, we find that EphA2 expression...
4.
Wang F, Hou W, Chitsike L, Xu Y, Bettler C, Perera A, et al.
Gastroenterology
. 2020 Mar;
159(1):289-305.e16.
PMID: 32171747
Background & Aims: We investigated whether ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1) is involved in development of hepatocellular carcinoma (HCC). Methods: We analyzed clinical and gene expression data from...
5.
Wang F, Bank T, Malnassy G, Arteaga M, Shang N, Dalheim A, et al.
Hepatol Commun
. 2018 Jun;
2(6):732-746.
PMID: 29881824
Hepatocellular carcinoma (HCC) is the fifth most common primary cancer and second largest cause of cancer-related death worldwide. The first-line oral chemotherapeutic agent sorafenib only increases survival in patients with...
6.
Kim J, Ha G, Campo L, Denning M, Patel T, Osipo C, et al.
Oncotarget
. 2017 Nov;
8(49):86799-86815.
PMID: 29156836
BRCA1 is an important player in the DNA damage response signaling, and its deficiency results in genomic instability. A complete loss or significantly reduced BRCA1 protein expression is often found...
7.
Haick J, Brueggemann L, Cribbs L, Denning M, Schwartz J, Byron K
Am J Physiol Lung Cell Mol Physiol
. 2017 Mar;
312(6):L822-L834.
PMID: 28283479
Kv7 potassium channels have recently been found to be expressed and functionally important for relaxation of airway smooth muscle. Previous research suggests that native Kv7 currents are inhibited following treatment...
8.
Arteaga M, Shang N, Ding X, Yong S, Cotler S, Denning M, et al.
Am J Physiol Gastrointest Liver Physiol
. 2016 Apr;
310(11):G1155-68.
PMID: 27125275
Liver fibrosis can progress to cirrhosis and result in serious complications of liver disease. The pathogenesis of liver fibrosis involves the activation of hepatic stellate cells (HSCs), the underlying mechanisms...
9.
Pandya K, Wyatt D, Gallagher B, Shah D, Baker A, Bloodworth J, et al.
Clin Cancer Res
. 2015 Sep;
22(1):175-86.
PMID: 26350262
Purpose: Breast cancer is the second leading cause of cancer mortality among women worldwide. The major problem with current treatments is tumor resistance, recurrence, and disease progression. ErbB-2-positive breast tumors...
10.
Driver J, Weber C, Callaci J, Kothari A, Zapf M, Roper P, et al.
J Biol Chem
. 2015 Feb;
290(16):9959-73.
PMID: 25713073
Alcohol (EtOH) intoxication is a risk factor for increased morbidity and mortality with traumatic injuries, in part through inhibition of bone fracture healing. Animal models have shown that EtOH decreases...