Miriam Cipullo
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Explore the profile of Miriam Cipullo including associated specialties, affiliations and a list of published articles.
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11
Citations
162
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Recent Articles
1.
Cipullo M, Valentin Gese G, Gopalakrishna S, Krueger A, Lobo V, Pirozhkova M, et al.
Nat Commun
. 2024 Jul;
15(1):5664.
PMID: 38969660
Mitochondrial gene expression relies on mitoribosomes to translate mitochondrial mRNAs. The biogenesis of mitoribosomes is an intricate process involving multiple assembly factors. Among these factors, GTP-binding proteins (GTPBPs) play important...
2.
Khawaja A, Cipullo M, Kruger A, Rorbach J
Trends Biochem Sci
. 2023 May;
48(7):629-641.
PMID: 37169615
The mitochondrial ribosome (mitoribosome) is a multicomponent machine that has unique structural features. Biogenesis of the human mitoribosome includes correct maturation and folding of the mitochondria-encoded RNA components (12S and...
3.
Remes C, Khawaja A, Pearce S, Dinan A, Gopalakrishna S, Cipullo M, et al.
Nucleic Acids Res
. 2023 Jan;
51(2):891-907.
PMID: 36629253
The synthesis of mitochondrial OXPHOS complexes is central to cellular metabolism, yet many molecular details of mitochondrial translation remain elusive. It has been commonly held view that translation initiation in...
4.
Itoh Y, Khawaja A, Laptev I, Cipullo M, Atanassov I, Sergiev P, et al.
Nature
. 2022 Jun;
606(7914):603-608.
PMID: 35676484
Mitoribosomes are essential for the synthesis and maintenance of bioenergetic proteins. Here we use cryo-electron microscopy to determine a series of the small mitoribosomal subunit (SSU) intermediates in complex with...
5.
Cipullo M, Valentin Gese G, Khawaja A, Hallberg B, Rorbach J
Nat Commun
. 2021 Jun;
12(1):3673.
PMID: 34135318
Mitochondrial ribosomes (mitoribosomes) synthesize a critical set of proteins essential for oxidative phosphorylation. Therefore, mitoribosomal function is vital to the cellular energy supply. Mitoribosome biogenesis follows distinct molecular pathways that...
6.
Shi Y, Yuan J, Rraklli V, Maxymovitz E, Cipullo M, Liu M, et al.
Nucleic Acids Res
. 2021 Feb;
49(5):2509-2521.
PMID: 33555349
The paucity of recurrent mutations has hampered efforts to understand and treat neuroblastoma. Alternative splicing and splicing-dependent RNA-fusions represent mechanisms able to increase the gene product repertoire but their role...
7.
Cipullo M, Pearce S, Lopez Sanchez I, Gopalakrishna S, Kruger A, Schober F, et al.
Nucleic Acids Res
. 2020 Dec;
49(1):354-370.
PMID: 33283228
Human mitoribosomes are macromolecular complexes essential for translation of 11 mitochondrial mRNAs. The large and the small mitoribosomal subunits undergo a multistep maturation process that requires the involvement of several...
8.
Pearce S, Cipullo M, Chung B, Brierley I, Rorbach J
Methods Mol Biol
. 2020 Nov;
2192:183-196.
PMID: 33230774
Ribosome profiling (Ribo-Seq) is a technique that allows genome-wide, quantitative analysis of translation. In recent years, it has found multiple applications in studies of translation in diverse organisms, tracking protein...
9.
Lopez Sanchez M, Cipullo M, Gopalakrishna S, Khawaja A, Rorbach J
Front Genet
. 2020 Aug;
11:761.
PMID: 32765591
Ribosomal RNA (rRNA) from all organisms undergoes post-transcriptional modifications that increase the diversity of its composition and activity. In mitochondria, specialized mitochondrial ribosomes (mitoribosomes) are responsible for the synthesis of...
10.
Busch J, Cipullo M, Atanassov I, Bratic A, Silva Ramos E, Schondorf T, et al.
Cell Rep
. 2019 Nov;
29(6):1728-1738.e9.
PMID: 31693908
Mitochondria harbor specialized ribosomes (mitoribosomes) necessary for the synthesis of key membrane proteins of the oxidative phosphorylation (OXPHOS) machinery located in the mitochondrial inner membrane. To date, no animal model...