Minh Thuan Nguyen Tran
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Explore the profile of Minh Thuan Nguyen Tran including associated specialties, affiliations and a list of published articles.
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9
Citations
73
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Recent Articles
1.
Mengiste A, McDonald J, Nguyen Tran M, Plank A, Wilson R, Butty V, et al.
ACS Synth Biol
. 2024 Aug;
13(9):2693-2701.
PMID: 39190860
Deaminase-T7 RNA polymerase fusion (MutaT7) proteins are a growing class of synthetic biology tools used to diversify target genes during laboratory evolution. To date, MutaT7 chimeras comprise either a deoxyadenosine...
2.
Denes C, Cole A, Nguyen Tran M, Khalid M, Hewitt A, Hesselson D, et al.
ACS Synth Biol
. 2022 Oct;
11(10):3544-3549.
PMID: 36219697
Directed evolution uses cycles of gene diversification and selection to generate proteins with novel properties. While traditionally directed evolution is performed in prokaryotic systems, recently a mammalian directed evolution system...
3.
Nguyen Tran M, Kc R, Hewitt A
CRISPR J
. 2022 Mar;
5(2):311-328.
PMID: 35244489
Base editors mediate the targeted conversion of single nucleobases in a therapeutically relevant manner. Herein, we present a hypothetical taxonomic and phylogenetic framework for the classification of more than 200...
4.
Stellon D, Nguyen Tran M, Talbot J, Chear S, Khalid M, Pebay A, et al.
Methods Mol Biol
. 2021 Sep;
2549:379-398.
PMID: 34505269
Genetically encoded fluorescent biosensors (GEFBs) enable researchers to visualize and quantify cellular processes in live cells. Induced pluripotent stem cells (iPSCs) can be genetically engineered to express GEFBs via integration...
5.
Wang Q, Chear S, Wing K, Stellon D, Nguyen Tran M, Talbot J, et al.
Methods
. 2021 Feb;
194:18-29.
PMID: 33607266
Induced pluripotent stem cells (iPSCs) have become widely used for disease modelling, particularly with regard to predisposing genetic risk factors and causal gene variants. Alongside this, technologies such as the...
6.
Nguyen Tran M, Rajendra K, Patterson F, Liu G, Cook A, Hewitt A
Methods
. 2021 Jan;
194:75-82.
PMID: 33484827
Precision chemistry entailing user-directed nucleotide substitutions and template-specified repair can be facilitated by base editing and prime editing, respectively. Recently, the diversification of adenine, cytosine, and prime editor variants obliges...
7.
Li F, Wing K, Wang J, Luu C, Bender J, Chen J, et al.
Front Cell Neurosci
. 2020 Nov;
14:570917.
PMID: 33132845
CRISPR/Cas has opened the prospect of direct gene correction therapy for some inherited retinal diseases. Previous work has demonstrated the utility of adeno-associated virus (AAV) mediated delivery to retinal cells...
8.
Nguyen Tran M, Khalid M, Wang Q, Walker J, Lidgerwood G, Dilworth K, et al.
Nat Commun
. 2020 Sep;
11(1):4871.
PMID: 32978399
Precision genome engineering has dramatically advanced with the development of CRISPR/Cas base editing systems that include cytosine base editors and adenine base editors (ABEs). Herein, we compare the editing profile...
9.
Nguyen Tran M, Khalid M, Pebay A, Cook A, Liang H, Wong R, et al.
Mol Vis
. 2019 Apr;
25:174-182.
PMID: 30996586
Purpose: To evaluate the efficacy of using a CRISPR/Cas-mediated strategy to correct a common high-risk allele that is associated with age-related macular degeneration (AMD; rs1061170; NM_000186.3:c.1204T>C; NP_000177.2:p.His402Tyr) in the complement...