Mingzong Li
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Explore the profile of Mingzong Li including associated specialties, affiliations and a list of published articles.
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12
Citations
85
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Recent Articles
1.
Li M, Konteatis Z, Nagaraja N, Chen Y, Zhou S, Ma G, et al.
J Med Chem
. 2022 Mar;
65(6):4600-4615.
PMID: 35293760
Inhibition of the -adenosyl methionine (SAM)-producing metabolic enzyme, methionine adenosyltransferase 2A (MAT2A), has received significant interest in the field of medicinal chemistry due to its implication as a synthetic lethal...
2.
Wright E, Fukuda S, Li M, Li Y, ODoherty G, Lannigan D
J Enzyme Inhib Med Chem
. 2021 Aug;
36(1):1798-1809.
PMID: 34348556
Identifying isoform-specific inhibitors for closely related kinase family members remains a substantial challenge. The necessity for achieving this specificity is exemplified by the RSK family, downstream effectors of ERK1/2, which...
3.
Li Y, Sandusky Z, Vemula R, Zhang Q, Wu B, Fukuda S, et al.
Org Lett
. 2020 Feb;
22(4):1448-1452.
PMID: 32009414
An asymmetric synthesis of two analogues of SL0101 () has been achieved. The effort is aimed at the discovery of inhibitors of the p90 ribosomal S6 kinase (RSK) with improved...
4.
Li M, Li Y, Ludwik K, Sandusky Z, Lannigan D, ODoherty G
Org Lett
. 2017 Apr;
19(9):2410-2413.
PMID: 28441024
A convergent synthesis of 5a-carbasugar analogues of the n-Pr-variant of SL0101 is described. The analogues were synthesized in an effort to find compounds with potent in vivo efficacy in the...
5.
Ludwik K, Campbell J, Li M, Li Y, Sandusky Z, Pasic L, et al.
Mol Cancer Ther
. 2016 Aug;
15(11):2598-2608.
PMID: 27528706
Metastatic breast cancer is an incurable disease and identification of novel therapeutic opportunities is vital. Triple-negative breast cancer (TNBC) frequently metastasizes and high levels of activated p90RSK (RSK), a downstream...
6.
Li M, Li Y, Mrozowski R, Sandusky Z, Shan M, Song X, et al.
ACS Med Chem Lett
. 2015 Jan;
6(1):95-9.
PMID: 25589938
The Ser/Thr protein kinase, RSK, is associated with oncogenesis, and therefore, there are ongoing efforts to develop RSK inhibitors that are suitable for use in vivo. SL0101 is a natural...
7.
Li M, Wang C, Fang P, Ge H
Chem Commun (Camb)
. 2011 May;
47(23):6587-9.
PMID: 21541423
A novel Pd-catalyzed decarboxylative cross-coupling of oxamic acids with potassium phenyltrifluoroborates has been realized under mild reaction conditions. This method provides an efficient access to N-mono- or N,N-disubstituted benzamides and...
8.
Li M, Wang C, Ge H
Org Lett
. 2011 Mar;
13(8):2062-4.
PMID: 21391715
A novel Pd-catalyzed decarboxylative cross-coupling of potassium aryltrifluoroborates with α-oxocarboxylic acids is performed at room temperature. This reaction provides an efficient access to aryl ketones under mild conditions.
9.
Fang P, Li M, Ge H
J Am Chem Soc
. 2010 Aug;
132(34):11898-9.
PMID: 20698536
A novel Pd-catalyzed decarboxylative ortho-acylation of acetanilides with alpha-oxocarboxylic acids is realized at room temperature. This reaction provides efficient access to o-acyl acetanilides under mild conditions.
10.
Li M, Ge H
Org Lett
. 2010 Jul;
12(15):3464-7.
PMID: 20670012
An efficient palladium-catalyzed decarboxylative acylation of unactivated arenes with alpha-oxocarboxylic acids is reported. This method provides a novel access to aryl ketones.