Mingkai Dai
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Explore the profile of Mingkai Dai including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
134
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Recent Articles
1.
Wang J, Dai M, Xing X, Wang X, Qin X, Huang T, et al.
Mol Oncol
. 2022 Oct;
17(1):150-172.
PMID: 36239411
Telomerase activation is required for malignant transformation. Recent advances in high-throughput technologies have enabled the generation of complex datasets, thus providing alternative approaches to exploring telomerase biology more comprehensively, which...
2.
Wang L, Wang L, Cheng G, Dai M, Yu Y, Teng G, et al.
Cell Mol Life Sci
. 2022 Jan;
79(2):110.
PMID: 35098380
The role of telomerase reverse transcriptase (TERT) induction and telomere maintenance in carcinogenesis including cervical cancer (CC) pathogenesis has been well established. However, it remains unclear whether they affect infection...
3.
Xing X, Yuan X, Liu T, Dai M, Fan Y, Liu C, et al.
J Cancer
. 2021 Jun;
12(13):3853-3861.
PMID: 34093793
The hotspot regulatory region mutations of the TERT, PLEKHS1 and GPR126 genes have been shown to occur frequently in urothelial bladder carcinoma (UBC). However, it is currently unclear whether these...
4.
Cheng G, Dai M, Xin Q, Wang L, Kong F, Xu D
Int J Clin Exp Pathol
. 2020 Sep;
13(8):2123-2129.
PMID: 32922609
Objective: Benign prostatic hyperplasia (BPH) is an age-related disease, occurring in >70% of men of age >60. Because telomeres and telomerase play a key role in aging and age-related diseases,...
5.
Cheng G, Wang L, Dai M, Wei F, Xu D
Int J Med Sci
. 2020 Sep;
17(14):2180-2186.
PMID: 32922179
The essential hypertension (EH) pathophysiology remains poorly understood. Many studies indicate that reduced leukocyte telomere length (LTL) is involved in the EH pathogenesis, however, the direct analysis of arterial telomere...
6.
Yuan X, Dai M, Xu D
Cancer Lett
. 2020 Aug;
493:1-9.
PMID: 32768523
The transcriptional de-repression of the telomerase reverse transcriptase (TERT) gene and subsequent activation of telomerase is a prerequisite step in malignant transformation and progression. Recently, the gain-of-function mutation of the...
7.
Sun Q, Liu J, Cheng G, Dai M, Liu J, Qi Z, et al.
J Transl Med
. 2020 May;
18(1):184.
PMID: 32366311
Background: Primary glomerulonephritis (GN) is the leading cause of chronic kidney disease (CKD) and frequently progresses into end stage renal diseases (ESRDs). Shorter leukocyte telomere length (LTL) has been implicated...
8.
Yuan X, Dai M, Xu D
Curr Top Med Chem
. 2020 Jan;
20(6):410-432.
PMID: 31903880
Telomeres are structurally nucleoprotein complexes at termini of linear chromosomes and essential to chromosome stability/integrity. In normal human cells, telomere length erodes progressively with each round of cell divisions, which...
9.
Guo Y, Yuan X, Li K, Dai M, Zhang L, Wu Y, et al.
Cell Death Differ
. 2019 Dec;
27(6):1862-1877.
PMID: 31802036
TERT promoter mutations occur in the majority of glioblastoma, bladder cancer (BC), and other malignancies while the ETS family transcription factors GABPA and its partner GABPB1 activate the mutant TERT...