Minghai Tang
Overview
Explore the profile of Minghai Tang including associated specialties, affiliations and a list of published articles.
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Articles
132
Citations
842
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Recent Articles
1.
Li Y, Zhang C, Tang D, Wang T, Yan W, Yang L, et al.
Proc Natl Acad Sci U S A
. 2025 Mar;
122(11):e2424098122.
PMID: 40067895
For decades, microtubules-composed of αβ-tubulin dimers-have been primary targets for cancer chemotherapy. While eight binding sites on the tubulin dimer have been structurally characterized, this study reveals a ninth. We...
2.
Su K, Tang M, Wu J, Ye N, Jiang X, Zhao M, et al.
Eur J Med Chem
. 2025 Mar;
289:117476.
PMID: 40056798
The NLRP3 inflammasome is crucial for immune responses. However, its overactivation can lead to severe inflammatory diseases, underscoring its importance as a target for therapeutic intervention. Although numerous inhibitors targeting...
3.
Yang L, Yang T, Wen Y, Tang M, Teng Y, Zhang W, et al.
J Med Chem
. 2025 Mar;
68(5):5333-5357.
PMID: 40022722
The application of drugs to regulate abnormal epigenetic changes has become an important means of tumor treatment. In this study, we employed computer-aided design methods to develop a novel deazapurine...
4.
Qin S, Xie L, Tang M, Ni H, Yang T
Bioorg Chem
. 2025 Jan;
156:108187.
PMID: 39864372
In this study, we reported the discovery of a novel type II c-Met/Axl inhibitor, characterized by using 4-amino-7H-pyrrolo[2,3-d]pyrimidine as a hinge region binder. Through a systematic exploration of the structure-activity...
5.
Guo T, Yuan Y, Zou Y, Guo Z, Yang T, Tang M, et al.
J Med Chem
. 2025 Jan;
68(2):1731-1754.
PMID: 39789975
Selective poly(ADP-ribose) polymerase 1 (PARP1) inhibitors not only exhibit antitumor efficacy but also offer the potential to mitigate the toxicities typically associated with broader PARP inhibition. In this study, we...
6.
Zhang R, Su K, Yang L, Duan H, Tang L, Tang M, et al.
J Med Chem
. 2024 Sep;
67(19):17472-17496.
PMID: 39311818
Chronic kidney disease (CKD) is a condition characterized by functional deterioration with sustained inflammation and progressive fibrosis of the kidneys affecting over 800 million people worldwide. The P2X7 receptor (P2X7R)...
7.
Zhang S, Wang X, Yang X, Ma Z, Liu P, Tang S, et al.
Arch Toxicol
. 2024 Aug;
98(11):3763-3775.
PMID: 39192019
Chlorfenapyr is a novel broad-spectrum insecticide derived from natural pyrrole derivatives produced by Streptomyces spp. It acts as a pro-insecticide and is metabolically converted to the active metabolite, tralopyril. Chlorfenapyr...
8.
Fu Z, Duan Y, Pei H, Zou Y, Tang M, Chen Y, et al.
J Med Chem
. 2024 Aug;
67(17):15711-15737.
PMID: 39169676
The NLRP3 inflammasome is a multiprotein complex that is a component of the innate immune system, involved in the production of pro-inflammatory cytokines. Its abnormal activation is associated with many...
9.
Wang P, Yuan Y, Yang T, Zou Y, Tang M, Ma Z, et al.
J Med Chem
. 2024 Aug;
67(17):15246-15267.
PMID: 39166848
Herein, we described the rational drug design and synthesis of a series of 5-amino-4-fluoro-1-benzo[]imidazole-6-carboxamide derivatives that inhibit MEK and RAF kinases. The detailed screening cascades revealed that was a preferred...
10.
Hu M, Yang T, Yang L, Niu L, Zhu J, Zhao A, et al.
Blood Cancer J
. 2024 Jun;
14(1):104.
PMID: 38926354
No abstract available.