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Milena Doroszko

Explore the profile of Milena Doroszko including associated specialties, affiliations and a list of published articles. Areas
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Citations 259
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Recent Articles
11.
Almstedt E, Elgendy R, Hekmati N, Rosen E, Warn C, Olsen T, et al.
Nat Commun . 2020 Jan; 11(1):71. PMID: 31900415
Despite advances in the molecular exploration of paediatric cancers, approximately 50% of children with high-risk neuroblastoma lack effective treatment. To identify therapeutic options for this group of high-risk patients, we...
12.
Doroszko M, Chrusciel M, Stelmaszewska J, Slezak T, Anisimowicz S, Plockinger U, et al.
Endocr Relat Cancer . 2018 Nov; 26(1):103-117. PMID: 30400009
Aberrantly expressed G protein-coupled receptors in tumors are considered as potential therapeutic targets. We analyzed the expressions of receptors of gonadotropin-releasing hormone (GNRHR), luteinizing hormone/chorionic gonadotropin (LHCGR) and follicle-stimulating hormone...
13.
Oduwole O, Peltoketo H, Poliandri A, Vengadabady L, Chrusciel M, Doroszko M, et al.
J Clin Invest . 2018 Mar; 128(5):1787-1792. PMID: 29584617
Spermatogenesis is regulated by the 2 pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This process is considered impossible without the absolute requirement of LH-stimulated testicular testosterone (T) production....
14.
Plockinger U, Chrusciel M, Doroszko M, Saeger W, Blankenstein O, Weizsacker K, et al.
J Endocr Soc . 2017 Dec; 1(1):57-71. PMID: 29264446
Context: Elevated human choriogonadotropin (hCG) may stimulate aberrantly expressed luteinizing hormone (LH)/hCG receptor (LHCGR) in adrenal glands, resulting in pregnancy-induced bilateral macronodular adrenal hyperplasia and transient Cushing syndrome (CS). Objective:...
15.
Doroszko M, Chrusciel M, Stelmaszewska J, Slezak T, Rivero-Muller A, Padzik A, et al.
Cell Physiol Biochem . 2017 Oct; 43(3):1064-1076. PMID: 28977799
Background/aims: Physiological role of luteinizing hormone (LH) and its receptor (LHCGR) in adrenal remains unknown. In inhibin-α/Simian Virus 40 T antigen (SV40Tag) (inhα/Tag) mice, gonadectomy-induced (OVX) elevated LH triggers the...
16.
Zareba I, Surazynski A, Chrusciel M, Miltyk W, Doroszko M, Rahman N, et al.
Cell Physiol Biochem . 2017 Sep; 43(2):670-684. PMID: 28942439
Background/aims: The effect of impaired intracellular proline availability for proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis was studied. Methods: We generated a constitutively knocked-down PRODH/POX MCF-7 breast cancer cell line (MCF-7shPRODH/POX) as...
17.
Doroszko M, Chrusciel M, Belling K, Vuorenoja S, Dalgaard M, Leffers H, et al.
Mol Cell Endocrinol . 2017 Jan; 444:9-18. PMID: 28131743
Specific inbred strains and transgenic inhibin-α Simian Virus 40 T antigen (inhα/Tag) mice are genetically susceptible to gonadectomy-induced adrenocortical neoplasias. We identified altered gene expression in prepubertally gonadectomized (GDX) inhα/Tag...
18.
Stelmaszewska J, Chrusciel M, Doroszko M, Akerfelt M, Ponikwicka-Tyszko D, Nees M, et al.
Sci Rep . 2016 Nov; 6:37095. PMID: 27848975
Expression of follicle-stimulation hormone receptor (FSHR) is confined to gonads and at low levels to some extragonadal tissues like human umbilical vein endothelial cells (HUVEC). FSH-FSHR signaling was shown to...
19.
Ponikwicka-Tyszko D, Chrusciel M, Stelmaszewska J, Bernaczyk P, Sztachelska M, Sidorkiewicz I, et al.
J Clin Endocrinol Metab . 2016 May; 101(7):2905-14. PMID: 27224263
Context: FSH receptor (FSHR), besides being expressed in gonads, is also expressed in some extragonadal tissues at low levels. Objective: We examined the functional expression of FSHR in different types...
20.
Kurowicka B, Chrusciel M, Zmijewska A, Doroszko M, Kotwica G, Rahman N
Cell Physiol Biochem . 2015 Apr; 35(5):1729-43. PMID: 25832132
Background: In comparison to short-term gonad heat exposure, little is known about the molecular mechanisms that regulate testicular steroidogenesis during long-term whole body heat acclimation. Material And Methods: Testicular slices...