Miklos Guttman
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Explore the profile of Miklos Guttman including associated specialties, affiliations and a list of published articles.
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74
Citations
3389
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Recent Articles
1.
Vance D, Freeman-Gallant G, McCarthy K, Piazza C, Chen Y, Vorauer C, et al.
Microbiol Spectr
. 2025 Feb;
:e0288324.
PMID: 39950825
Broadly protective immunity to the Lyme disease spirochete, , is constrained by antibodies against type-specific epitopes on outer surface protein C (OspC), a homodimeric helix-rich lipoprotein essential for early stages...
2.
Tuttle L, James E, Georgescauld F, Wales T, Weis D, Engen J, et al.
J Am Soc Mass Spectrom
. 2025 Jan;
36(2):416-423.
PMID: 39837577
An inherent strength of hydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) is its ability to detect the presence of multiple conformational states of a protein, which often manifest as multimodal...
3.
Moroco J, Moroco J, Jacome A, Beltran P, Reiter A, Mundorff C, et al.
Mol Cell Proteomics
. 2025 Jan;
24(2):100904.
PMID: 39788320
Despite the widespread use of MS for hydrogen/deuterium exchange measurements, no systematic, large-scale study has been conducted to compare the observed exchange rates in protein-derived, unstructured peptides measured by MS...
4.
Cao S, Garcia S, Shi H, James E, Kito Y, Shi H, et al.
Cell
. 2024 Nov;
187(26):7568-7584.e22.
PMID: 39504958
Ubiquitin-dependent proteolysis regulates diverse cellular functions with high substrate specificity, which hinges on the ability of ubiquitin E3 ligases to decode the targets' degradation signals, i.e., degrons. Here, we show...
5.
Vorauer C, Boniche-Alfaro C, Murphree T, Matsui T, Weiss T, Fries B, et al.
Anal Chem
. 2024 Oct;
96(42):16758-16767.
PMID: 39434663
Elucidating the interactions that drive antigen recognition is central to understanding antibody-mediated protection and is vital for the rational design of immunogens. Often, structural knowledge of epitopes targeted by antibodies...
6.
Rudolph M, Chen Y, Vorauer C, Vance D, Piazza C, Willsey G, et al.
J Immunol
. 2024 Sep;
213(8):1234-1243.
PMID: 39240158
Lyme disease is a tick-borne, multisystem infection caused by the spirochete Borreliella burgdorferi. Although Abs have been implicated in the resolution of Lyme disease, the specific B cell epitopes targeted...
7.
Janowska M, Reiter K, Magala P, Guttman M, Klevit R
Bioinformatics
. 2024 Jul;
40(8).
PMID: 39078213
Summary: Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) is a powerful protein characterization technique that provides insights into protein dynamics and flexibility at the peptide level. However, analyzing HDX-MS data presents a...
8.
Francis K, Zheng H, Suskind D, Murphree T, Phan B, Quah E, et al.
Sci Rep
. 2024 May;
14(1):11839.
PMID: 38782973
The intestinal extracellular matrix (ECM) helps maintain appropriate tissue barrier function and regulate host-microbial interactions. Chondroitin sulfate- and dermatan sulfate-glycosaminoglycans (CS/DS-GAGs) are integral components of the intestinal ECM, and alterations...
9.
Rudolph M, Chen Y, Vorauer C, Vance D, Piazza C, Willsey G, et al.
bioRxiv
. 2024 May;
PMID: 38746285
Lyme disease is a tick-borne, multisystem infection caused by the spirochete, . Although antibodies have been implicated in the resolution of Lyme disease, the specific B cell epitopes targeted during...
10.
James E, Baggett D, Chang E, Schachter J, Nixey T, Choi K, et al.
bioRxiv
. 2024 Feb;
PMID: 38352474
Microtubule-associated protein tau is an intrinsically disordered protein (IDP) that forms characteristic fibrillar aggregates in several diseases, the most well-known of which is Alzheimer's disease (AD). Despite keen interest in...