Mike Heilemann
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Explore the profile of Mike Heilemann including associated specialties, affiliations and a list of published articles.
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181
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5579
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Recent Articles
1.
Catapano C, Dietz M, Kompa J, Jang S, Freund P, Johnsson K, et al.
Angew Chem Int Ed Engl
. 2024 Nov;
64(1):e202413117.
PMID: 39545345
Single-particle tracking (SPT) has become a powerful tool to monitor the dynamics of membrane proteins in living cells. However, permanent labeling strategies for SPT suffer from photobleaching as a major...
2.
Li Y, Arghittu S, Dietz M, Hella G, Hasse D, Ferraris D, et al.
Nat Commun
. 2024 Nov;
15(1):9486.
PMID: 39488533
Embedding of cell-surface receptors into a membrane defines their dynamics but also complicates experimental characterization of their signaling complexes. The hepatocyte growth factor receptor MET is a receptor tyrosine kinase...
3.
Saguy A, Nahimov T, Lehrman M, Gomez-de-Mariscal E, Hidalgo-Cenalmor I, Alalouf O, et al.
Small Methods
. 2024 Oct;
:e2400672.
PMID: 39400948
Generative models, such as diffusion models, have made significant advancements in recent years, enabling the synthesis of high-quality realistic data across various domains. Here, the adaptation and training of a...
4.
Balakrishnan A, Glogger M, Heilemann M
Methods Mol Biol
. 2024 Aug;
2845:127-140.
PMID: 39115662
Selective autophagy of the endoplasmic reticulum (ER-phagy) is a mechanism that is necessary for degrading damaged ER components and preventing cells from experiencing ER stress. Various ER-phagy receptors orchestrate this...
5.
Mineev K, Hargittay B, Jin J, Catapano C, Dietz M, Segarra M, et al.
FEBS Lett
. 2024 Jul;
598(20):2518-2532.
PMID: 38997225
SSR128129E (SSR) is a unique small-molecule inhibitor of fibroblast growth factor receptors (FGFRs). SSR is a high-affinity allosteric binder that selectively blocks one of the two major FGFR-mediated pathways. The...
6.
Kessler L, Balakrishnan A, Menche T, Wang D, Li Y, Mantel M, et al.
J Phys Chem B
. 2024 Jul;
128(28):6751-6759.
PMID: 38955346
Protein labeling through transient and repetitive hybridization of short, fluorophore-labeled DNA oligonucleotides has become widely applied in various optical super-resolution microscopy methods. The main advantages are multitarget imaging and molecular...
7.
Abraham B, Haikarainen T, Vuorio J, Girych M, Virtanen A, Kurttila A, et al.
Sci Adv
. 2024 Mar;
10(10):eadl2097.
PMID: 38457493
Janus kinase 2 (JAK2) mediates type I/II cytokine receptor signaling, but JAK2 is also activated by somatic mutations that cause hematological malignancies by mechanisms that are still incompletely understood. Quantitative...
8.
Klevanski M, Kim H, Heilemann M, Kuner T, Bartenschlager R
Antiviral Res
. 2024 Mar;
225:105856.
PMID: 38447646
Four years after its outbreak, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a global challenge for human health. At its surface, SARS-CoV-2 features numerous extensively glycosylated spike proteins. This...
9.
Bestsennaia E, Maslov I, Balandin T, Alekseev A, Yudenko A, Abu Shamseye A, et al.
Angew Chem Int Ed Engl
. 2024 Jan;
63(11):e202307555.
PMID: 38226794
Microbial rhodopsins are retinal membrane proteins that found a broad application in optogenetics. The oligomeric state of rhodopsins is important for their functionality and stability. Of particular interest is the...
10.
Berkane R, Ho-Xuan H, Glogger M, Sanz-Martinez P, Brunello L, Glaesner T, et al.
Nat Commun
. 2023 Dec;
14(1):8364.
PMID: 38102139
Selective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator of ER remodeling and essential to maintain cellular homeostasis during environmental changes. We recently showed that...