Sebastian Malkusch
Overview
Explore the profile of Sebastian Malkusch including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
633
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Recent Articles
1.
Lotsch J, Gasimli K, Malkusch S, Hahnefeld L, Angioni C, Schreiber Y, et al.
Elife
. 2024 Sep;
13.
PMID: 39347767
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a serious therapy-limiting side effect of commonly used anticancer drugs. Previous studies suggest that lipids may play a role in CIPN. Therefore, the present...
2.
Malkusch S, Rahm J, Dietz M, Heilemann M, Sibarita J, Lotsch J
Mol Biol Cell
. 2022 Feb;
33(6):ar60.
PMID: 35171646
Internalin B-mediated activation of the membrane-bound receptor tyrosine kinase MET is accompanied by a change in receptor mobility. Conversely, it should be possible to infer from receptor mobility whether a...
3.
Malkusch S, Hahnefeld L, Gurke R, Lotsch J
CPT Pharmacometrics Syst Pharmacol
. 2021 Oct;
10(11):1371-1381.
PMID: 34598320
The evaluation of pharmacological data using machine learning requires high data quality. Therefore, data preprocessing, that is, cleaning analytical laboratory errors, replacing missing values or outliers, and transforming data adequately...
4.
Lotsch J, Malkusch S, Ultsch A
PLoS One
. 2021 Aug;
16(8):e0255838.
PMID: 34352006
Motivation: The size of today's biomedical data sets pushes computer equipment to its limits, even for seemingly standard analysis tasks such as data projection or clustering. Reducing large biomedical data...
5.
Kringel D, Malkusch S, Lotsch J
Int J Mol Sci
. 2021 Jul;
22(14).
PMID: 34298869
Interactions of drugs with the classical epigenetic mechanism of DNA methylation or histone modification are increasingly being elucidated mechanistically and used to develop novel classes of epigenetic therapeutics. A data...
6.
Kringel D, Malkusch S, Kalso E, Lotsch J
Int J Mol Sci
. 2021 Jan;
22(2).
PMID: 33467215
The genetic background of pain is becoming increasingly well understood, which opens up possibilities for predicting the individual risk of persistent pain and the use of tailored therapies adapted to...
7.
Lotsch J, Malkusch S
Eur J Pain
. 2020 Oct;
25(2):442-465.
PMID: 33064864
Background: In pain research and clinics, it is common practice to subgroup subjects according to shared pain characteristics. This is often achieved by computer-aided clustering. In response to a recent...
8.
Lotsch J, Kringel D, Geisslinger G, Oertel B, Resch E, Malkusch S
Int J Mol Sci
. 2020 Jun;
21(12).
PMID: 32575443
Genetic association studies have shown their usefulness in assessing the role of ion channels in human thermal pain perception. We used machine learning to construct a complex phenotype from pain...
9.
Weinelt N, Karathanasis C, Smith S, Medler J, Malkusch S, Fulda S, et al.
J Leukoc Biol
. 2020 May;
109(2):363-371.
PMID: 32401398
TNFR1 is a crucial regulator of NF-ĸB-mediated proinflammatory cell survival responses and programmed cell death (PCD). Deregulation of TNFα- and TNFR1-controlled NF-ĸB signaling underlies major diseases, like cancer, inflammation, and...
10.
Harwardt M, Schroder M, Li Y, Malkusch S, Freund P, Gupta S, et al.
Int J Mol Sci
. 2020 Apr;
21(8).
PMID: 32316583
Receptor tyrosine kinases (RTKs) orchestrate cell motility and differentiation. Deregulated RTKs may promote cancer and are prime targets for specific inhibitors. Increasing evidence indicates that resistance to inhibitor treatment involves...