Mike Aguiar
Overview
Explore the profile of Mike Aguiar including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
1192
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Recent Articles
1.
Koide E, Mohardt M, Doctor Z, Yang A, Hao M, Donovan K, et al.
Chembiochem
. 2023 Apr;
24(19):e202300141.
PMID: 37088717
Focal adhesion kinase (FAK) is an attractive drug target due to its overexpression in cancer. FAK functions as a non-receptor tyrosine kinase and scaffolding protein, coordinating several downstream signaling effectors...
2.
Gassaway B, Li J, Rad R, Mintseris J, Mohler K, Levy T, et al.
Nat Methods
. 2022 Oct;
19(11):1371-1375.
PMID: 36280721
Mass-spectrometry-based phosphoproteomics has become indispensable for understanding cellular signaling in complex biological systems. Despite the central role of protein phosphorylation, the field still lacks inexpensive, regenerable, and diverse phosphopeptides with...
3.
Chen D, Xia S, Wang M, Lin R, Li Y, Mao H, et al.
Cancer Discov
. 2019 Mar;
9(6):756-777.
PMID: 30862724
Isocitrate dehydrogenase 1 (IDH1) is important for reductive carboxylation in cancer cells, and the IDH1 R132H mutation plays a pathogenic role in cancers including acute myeloid leukemia (AML). However, the...
4.
Liew G, Ye F, Nager A, Murphy J, Lee J, Aguiar M, et al.
Dev Cell
. 2014 Dec;
31(3):265-278.
PMID: 25443296
The sorting of signaling receptors into and out of cilia relies on the BBSome, a complex of Bardet-Biedl syndrome (BBS) proteins, and on the intraflagellar transport (IFT) machinery. GTP loading...
5.
Semenova I, Ikeda K, Resaul K, Kraikivski P, Aguiar M, Gygi S, et al.
Mol Biol Cell
. 2014 Aug;
25(20):3119-32.
PMID: 25143402
Microtubule (MT)-based transport of organelles driven by the opposing MT motors kinesins and dynein is tightly regulated in cells, but the underlying molecular mechanisms remain largely unknown. Here we tested...
6.
Fan J, Kang H, Shan C, Elf S, Lin R, Xie J, et al.
J Biol Chem
. 2014 Aug;
289(38):26533-26541.
PMID: 25104357
The mitochondrial pyruvate dehydrogenase complex (PDC) plays a crucial role in regulation of glucose homoeostasis in mammalian cells. PDC flux depends on catalytic activity of the most important enzyme component...
7.
Shan C, Kang H, Elf S, Xie J, Gu T, Aguiar M, et al.
J Biol Chem
. 2014 Jun;
289(31):21413-22.
PMID: 24962578
Many cancer cells rely more on aerobic glycolysis (the Warburg effect) than mitochondrial oxidative phosphorylation and catabolize glucose at a high rate. Such a metabolic switch is suggested to be...
8.
Fan J, Shan C, Kang H, Elf S, Xie J, Tucker M, et al.
Mol Cell
. 2014 Feb;
53(4):534-48.
PMID: 24486017
Mitochondrial pyruvate dehydrogenase complex (PDC) is crucial for glucose homeostasis in mammalian cells. The current understanding of PDC regulation involves inhibitory serine phosphorylation of pyruvate dehydrogenase (PDH) by PDH kinase...
9.
Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee K, et al.
Mol Cell Proteomics
. 2013 Oct;
13(1):372-87.
PMID: 24129315
Protein methylation is a common posttranslational modification that mostly occurs on arginine and lysine residues. Arginine methylation has been reported to regulate RNA processing, gene transcription, DNA damage repair, protein...
10.
Janas M, Wang B, Harris A, Aguiar M, Shaffer J, Subrahmanyam Y, et al.
RNA
. 2012 Sep;
18(11):2041-55.
PMID: 23019594
MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate protein output from the majority of human mRNAs. In contrast to the consensus view that all miRNAs are associated with Argonaute...